Combined antifungal therapy with immunostimulation for refractory cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus

被引：0

作者：

Mhenni, Rania ^{[1
,2
]}

Delliere, Sarah ^{[3
,4
]}

Ben Maaouia, Chiheb ^{[1
,2
]}

Hamane, Samia ^{[4
]}

Deniau, Benjamin ^{[1
,2
,3
,5
,6
,7
]}

Mahevas, Thibault ^{[8
]}

Chaussard, Maite ^{[1
,2
]}

Coutrot, Maxime ^{[1
,2
]}

Guillemet, Lucie ^{[1
,2
]}

Cupaciu, Alexandru ^{[1
,2
]}

Pharaboz, Alexandre ^{[1
,2
]}

Walter, Thais ^{[1
,2
,3
]}

Boutin, Louis ^{[1
,2
,3
,5
]}

Benyamina, Mourad ^{[1
,2
]}

Corte, Helene ^{[9
]}

Delale, Charles ^{[10
]}

Chaouat, Marc ^{[3
,11
]}

Guihot, Amelie

Lanternier, Fanny ^{[3
,12
]}

Alanio, Alexandre ^{[3
,4
]}

Depret, Francois ^{[1
,2
,3
,5
,6
,7
]}

Serris, Alexandra ^{[3
,12
]}

Dudoignon, Emmanuel ^{[1
,2
,3
,5
,6
,7
]}

机构：

[1] Grp Hosp St Louis Lariboisiere, AP HP, Dept Anesthesiol, 1 Ave Claude Vellefaux, F-75010 Paris, France

[2] Crit Care & Burn Unit, 1 Ave Claude Vellefaux, F-75010 Paris, France

[3] Univ Paris Cite, Paris, France

[4] Dept Mycol & Parasitol, Paris, France

[5] Grp Hosp St Louis Lariboisiere, Lariboisiere Hosp, AP HP, France Inst Natl Sante & Rech Med INSERM,INSERM UM, Paris, France

[6] INI CRCT Network, Nancy, France

[7] FHU PROMICE, Paris, France

[8] St Louis Hosp, Dept Dermatol, St Louis, France

[9] St Louis Hosp, AP HP, Abdominal Surg, St Louis, France

[10] CH Blois, Intens Care Unit, Blois, France

[11] St Louis Hosp, AP HP, Plast Surg, St Louis, France

[12] Hop Necker Enfants Malad, Dept Infect Dis, Paris, France

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2025年 / 111卷 / 03期

关键词：

Immunostimulation; Immunotherapy; Mucormycosis; Rhizopus microsporus; NIVOLUMAB;

D O I：

10.1016/j.diagmicrobio.2024.116653

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Mucormycosis is a fungal infection typically affecting immunocompromised patients. Here, we report a severe case of invasive cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus, successfully treated with a combination of antifungal therapy, PD-1 inhibitor, and interferon-gamma. We highlight the importance of personalized immunotherapy in refractory cases of invasive mucormycosis.

引用

页数：5

共 48 条

[31] Impairment of Th cell response in Card9 knockout mice with cutaneous mucormycosis caused by Rhizopus arrhizus
Sun, Lingyue
Wan, Zhe
Li, Ruoyu
Yu, Jin
EXPERIMENTAL DERMATOLOGY, 2019, 28 (11) : 1244 - 1251
[32] Disseminated Rhizopus microsporus infection cured by salvage allogeneic hematopoietic stem cell transplantation, antifungal combination therapy, and surgical resection
Lebeau, O.
Van Delden, C.
Garbino, J.
Robert, J.
Lamoth, F.
Passweg, J.
Chalandon, Y.
TRANSPLANT INFECTIOUS DISEASE, 2010, 12 (03) : 269 - 272
[33] Successful medical and antifungal therapy of Rhizopus oryzae rhino-cerebral mucormycosis without surgical treatment.
Nevez, G
Massip, P
Linas, MD
Lellouche, B
Tubery, M
Carme, B
Pessey, JJ
Duffaut, M
Seguela, JP
JOURNAL DE MYCOLOGIE MEDICALE, 1995, 5 (04): : 254 - 258
[34] Case report: Disseminated mucormycosis misdiagnosed as malignancy developed from allergic bronchopulmonary mycosis caused by Rhizopus microsporus following SARS-CoV-2 infection in a woman
Kong, Chengying
Zong, Laibin
Ji, Shunxian
Liu, Yangxiang
Li, Miaomiao
FRONTIERS IN MEDICINE, 2024, 11
[35] POST-TRAUMATIC CUTANEOUS MUCORMYCOSIS IN DIABETES-MELLITUS - SHORT-TERM ANTIFUNGAL THERAPY
RYANPOIRIER, K
EISEMAN, RM
BEATY, JH
HUNT, PG
BURGHEN, GA
LEGGIADRO, RJ
CLINICAL PEDIATRICS, 1988, 27 (12) : 609 - 612
[36] Posaconazole combined with amphotericin B, an effective therapy for a murine disseminated infection caused by Rhizopus oryzae
Rodriguez, M. Mar
Serena, Carolina
Marine, Marcal
Pastor, F. Javier
Guarro, Josep
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (10) : 3786 - 3788
[37] Successful treatment of refractory cutaneous infection caused by Mycobacterium marinum with a combined regimen containing amikacin
Huang, Yingxue
Xu, Xiulian
Liu, Yi
Wu, Kan
Zhang, Wei
Liu, Pai
Zeng, Xuesi
Sun, Jianfang
Jiang, Yiqun
Wang, Hongsheng
CLINICAL INTERVENTIONS IN AGING, 2012, 7 : 533 - 538
[38] Efficacy of rituximab combined with cyclophosphamide in a patient with systemic lupus erythematosus and peritoneal vasculitis refractory to conventional inmunosupressive therapy
Garrido Rasco, Rocio
Garcia Hernandez, Francisco Jose
Gonzalez Leon, Rocio
Castillo Palma, Maria Jesus
Ocana Medina, Celia
Sanchez Roman, Julio
REUMATOLOGIA CLINICA, 2009, 5 (01): : 28 - 30
[39] Fire needle combined with photodynamic therapy for cutaneous infectious granulomatosis caused by mycobacterium chelonae: A case report
Tang, Lei
Huang, Fujun
Zhou, Xun
Zhao, Mingdan
Huang, Mengya
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2024, 45
[40] Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers
Tian, Dan
Teng, Chong
Lv, Yanju
Duan, Xiaozhuo
Wang, Yi
Song, Xiaowei
Jiang, Qiuying
Huang, Dayong
Xin, Tao
Yang, Yu
Li, Li
DISCOVER ONCOLOGY, 2024, 15 (01)

← 1 2 3 4 5 →