Combined antifungal therapy with immunostimulation for refractory cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus

被引：0

作者：

Mhenni, Rania ^{[1
,2
]}

Delliere, Sarah ^{[3
,4
]}

Ben Maaouia, Chiheb ^{[1
,2
]}

Hamane, Samia ^{[4
]}

Deniau, Benjamin ^{[1
,2
,3
,5
,6
,7
]}

Mahevas, Thibault ^{[8
]}

Chaussard, Maite ^{[1
,2
]}

Coutrot, Maxime ^{[1
,2
]}

Guillemet, Lucie ^{[1
,2
]}

Cupaciu, Alexandru ^{[1
,2
]}

Pharaboz, Alexandre ^{[1
,2
]}

Walter, Thais ^{[1
,2
,3
]}

Boutin, Louis ^{[1
,2
,3
,5
]}

Benyamina, Mourad ^{[1
,2
]}

Corte, Helene ^{[9
]}

Delale, Charles ^{[10
]}

Chaouat, Marc ^{[3
,11
]}

Guihot, Amelie

Lanternier, Fanny ^{[3
,12
]}

Alanio, Alexandre ^{[3
,4
]}

Depret, Francois ^{[1
,2
,3
,5
,6
,7
]}

Serris, Alexandra ^{[3
,12
]}

Dudoignon, Emmanuel ^{[1
,2
,3
,5
,6
,7
]}

机构：

[1] Grp Hosp St Louis Lariboisiere, AP HP, Dept Anesthesiol, 1 Ave Claude Vellefaux, F-75010 Paris, France

[2] Crit Care & Burn Unit, 1 Ave Claude Vellefaux, F-75010 Paris, France

[3] Univ Paris Cite, Paris, France

[4] Dept Mycol & Parasitol, Paris, France

[5] Grp Hosp St Louis Lariboisiere, Lariboisiere Hosp, AP HP, France Inst Natl Sante & Rech Med INSERM,INSERM UM, Paris, France

[6] INI CRCT Network, Nancy, France

[7] FHU PROMICE, Paris, France

[8] St Louis Hosp, Dept Dermatol, St Louis, France

[9] St Louis Hosp, AP HP, Abdominal Surg, St Louis, France

[10] CH Blois, Intens Care Unit, Blois, France

[11] St Louis Hosp, AP HP, Plast Surg, St Louis, France

[12] Hop Necker Enfants Malad, Dept Infect Dis, Paris, France

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2025年 / 111卷 / 03期

关键词：

Immunostimulation; Immunotherapy; Mucormycosis; Rhizopus microsporus; NIVOLUMAB;

D O I：

10.1016/j.diagmicrobio.2024.116653

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Mucormycosis is a fungal infection typically affecting immunocompromised patients. Here, we report a severe case of invasive cutaneous and peritoneal mucormycosis caused by Rhizopus microsporus, successfully treated with a combination of antifungal therapy, PD-1 inhibitor, and interferon-gamma. We highlight the importance of personalized immunotherapy in refractory cases of invasive mucormycosis.

引用

页数：5

共 48 条

[21] Primary Cutaneous Mucormycosis Caused by Rhizopus oryzae: A Case Report and Review of Literature
Rodriguez-Lobato, Erika
Ramirez-Hobak, Lourdes
Aquino-Matus, Jorge E.
Ramirez-Hinojosa, Juan P.
Lozano-Fernandez, Victor H.
Xicohtencatl-Cortes, Juan
Hernandez-Castro, Rigoberto
Arenas, Roberto
MYCOPATHOLOGIA, 2017, 182 (3-4) : 387 - 392
[22] Primary Cutaneous Mucormycosis Caused by Rhizopus oryzae in a Pediatric Patient with IgA Nephropathy
Wu, YiFan
Duan, YuanYuan
Chen, QiYing
He, YiFan
Dang, YongChao
Li, JiaWei
Liu, Fang
Kong, QingTao
Sang, Hong
MYCOPATHOLOGIA, 2023, 188 (03) : 275 - 277
[23] Primary Cutaneous Mucormycosis Caused by Rhizopus oryzae: A Case Report and Review of Literature
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Lourdes Ramírez-Hobak
Jorge E. Aquino-Matus
Juan P. Ramírez-Hinojosa
Víctor H. Lozano-Fernández
Juan Xicohtencatl-Cortes
Rigoberto Hernández-Castro
Roberto Arenas
Mycopathologia, 2017, 182 : 387 - 392
[24] Diagnosis of cutaneous mucormycosis due to Rhizopus microsporus by an innovative PCR-restriction fragment-length polymorphism method
Laché, J
Machouart, M
Burton, K
Collomb, J
Biava, MF
Gérard, A
Fortier, B
CLINICAL INFECTIOUS DISEASES, 2005, 41 (09) : 1362 - 1365
[25] Gangrenous Cutaneous Mucormycosis Caused by Rhizopus oryzae: A Case Report and Review of Primary Cutaneous Mucormycosis in China Over Past 20 Years
HouMin Li
Sonia Kay Hwang
Cheng Zhou
Juan Du
JianZhong Zhang
Mycopathologia, 2013, 176 : 123 - 128
[26] Gangrenous Cutaneous Mucormycosis Caused by Rhizopus oryzae: A Case Report and Review of Primary Cutaneous Mucormycosis in China Over Past 20 Years
Li, HouMin
Hwang, Sonia Kay
Zhou, Cheng
Du, Juan
Zhang, JianZhong
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[27] Continuous debridement combined with short-term posaconazole therapy for cutaneous mucormycosis caused by Rhizopus oryzae infection secondary to acute myeloid leukemia: a case report
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Li, Jv
Xie, Yilian
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[28] Cutaneous mucormycosis by Rhizopus arrhizus treated with isavuconazole as first line therapy: A case report
Zuglian, G.
Ripamonti, D.
Tebaldi, A.
Rizzi, M.
MEDICAL MYCOLOGY CASE REPORTS, 2019, 26 : 42 - 43
[29] Successful Use of Granulocyte Infusions with Triple Antifungal Therapy in Disseminated Cutaneous Mucormycosis
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Singhal, T.
Tulpule, S.
Gupta, S.
Sen, S.
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[30] COMBINED ANTIFUNGAL THERAPY FOR CHRONIC REFRACTORY AIRWAY MYCOSIS
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