An early economic evaluation of active surveillance for low-risk ductal carcinoma in situ

被引：0
|
作者：
Byng, Danalyn [1 ,2 ]
Schaapveld, Michael [1 ]
Lips, Esther H. [3 ]
van Duijnhoven, Frederieke H. [4 ]
Wesseling, Jelle [3 ,5 ]
van Harten, Wim H. [1 ,2 ]
Retel, Valesca P. [1 ,2 ]
机构：
[1] Netherlands Canc Inst Antoni van Leeuwenhoek Hosp, Div Psychosocial Res & Epidemiol, NL-1066 CX Amsterdam, Netherlands
[2] Erasmus Univ, Erasmus Sch Hlth Policy & Management, NL-3062 PA Rotterdam, Netherlands
[3] Netherlands Canc Inst Antoni van Leeuwenhoek Hosp, Div Mol Pathol, NL-1066 CX Amsterdam, Netherlands
[4] Netherlands Canc Inst Antoni van Leeuwenhoek Hosp, Div Surg Oncol, NL-1066 CX Amsterdam, Netherlands
[5] Leiden Univ Med Ctr, Dept Pathol, NL-2333 ZA Leiden, Netherlands
来源：
FUTURE ONCOLOGY | 2024年 / 20卷 / 40期
关键词：
active surveillance; biomarkers; cost-effectiveness; ductal carcinoma in situ; early economic evaluation; CLINICAL-PRACTICE GUIDELINES; COST-EFFECTIVENESS ANALYSIS; INVASIVE BREAST-CANCER; CONTINUOUS-TIME; MARKOV-MODELS; PHASE-III; FOLLOW-UP; RADIOTHERAPY; RECURRENCE; SURGERY;
D O I：
10.1080/14796694.2024.2421152
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Perform early economic evaluation comparing active surveillance (AS) to surgery for women with low-risk ductal carcinoma in situ, a precursor of invasive breast cancer. Materials & methods: A 10-year incremental costs (Euro) and quality-adjusted life years (QALYs) were compared between a simulated cohort of women undergoing breast conserving surgery +/- radiotherapy, and a cohort with a low-risk subgroup undergoing AS using a semi-Markov model. Scenario and headroom analyses evaluated a better-performing biomarker to select low-risk women for AS. Results: AS resulted in lower costs and survival, but higher QALYs (0.40). Scenario analyses maintained survival outcomes and maximized QALYs. Conclusion: AS for low-risk ductal carcinoma in situ is cost-effective, but a better-performing biomarker to select low-risk women can maximize quality-adjusted outcomes.
引用
收藏
页码：3451 / 3462
页数：12
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