IRE1α-XBP1 moonlighting to restrict leukemia

被引：0
|
作者：
Xie, Stephanie Z. [1 ]
机构：
[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada
来源：
NATURE IMMUNOLOGY | 2025年 / 26卷 / 02期
关键词：
PATHWAYS;
D O I：
10.1038/s41590-024-02061-y
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by repressing pro-leukemogenic programs, independent of the unfolded protein response. A treatment strategy for acute myeloid leukemia could involve activation of the IRE1α–XBP1 axis to suppress WNT/β-catenin signaling.
引用
收藏
页码：157 / 158
页数：2
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