IRE1α-XBP1 moonlighting to restrict leukemia

被引：0

作者：

Xie, Stephanie Z. ^{[1
]}

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada

来源：

NATURE IMMUNOLOGY | 2025年 / 26卷 / 02期

关键词：

PATHWAYS;

D O I：

10.1038/s41590-024-02061-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by repressing pro-leukemogenic programs, independent of the unfolded protein response. A treatment strategy for acute myeloid leukemia could involve activation of the IRE1α–XBP1 axis to suppress WNT/β-catenin signaling.

引用

页码：157 / 158

页数：2

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