Synthesis of New Class of Spirochromanone/Isoxazole/Isoxazoline Derivatives as Potential Antimicrobial Agents

被引：0
|
作者：
Raju, M. [1 ,2 ]
Hemasri, Y. [1 ]
Rao, Y. Jayaprakash [3 ]
机构：
[1] Osmania Univ, Dept Chem, Nizam Coll, Hyderabad 500001, India
[2] Govt Degree Coll, Alair 508101, India
[3] Osmania Univ, Univ Coll Sci Saifabad, Dept Chem, Hyderabad 500004, India
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2024年 / 94卷 / 09期
关键词：
spirochromanone; 1,3-dipolar cycloaddition; chromanone; isoxazole; isooxazoline; ANTIOXIDANT ACTIVITY; ISOXAZOLINES; ANTICANCER; DESIGN;
D O I：
10.1134/S107036322409024X
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AbstractA series of novel hybrid derivatives of spirochromanone and isoxazole/isoxazoline was synthesized by 1,3-dipolar cycloaddition of the corresponding spirochromanone alkyne/alkene with nitrile oxides, in situ generated from substituted oximes in the presence of eco-friendly oxidant (sodium hypochlorite) under mild reaction conditions. All new compounds were structurally characterized by 1H, 13C NMR and HRMS techniques. All synthesized compounds were evaluated for their antimicrobial and antifungal activities.
引用
收藏
页码：2460 / 2469
页数：10
相关论文
共 50 条
  • [41] NEW SYNTHESIS OF PYRAZOLE AND ISOXAZOLE DERIVATIVES
    MOLINA, P
    FRESNEDA, PM
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1984, 21 (02) : 461 - 464
  • [42] Synthesis of New Spirooxindole-Fused Isoxazoline/Triazole and Isoxazoline/Isoxazole Derivatives from Three-Component 1,3-Dipolar Cycloaddition
    Sakly, Randa
    Edziri, Hayet
    Askri, Moheddine
    Knorr, Michael
    Louven, Kathrin
    Strohmann, Carsten
    Mastouri, Maha
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 54 (06) : 3554 - 3564
  • [43] Design, synthesis and evaluation of carbazole derivatives as potential antimicrobial agents
    Xue, Yi-Jie
    Li, Ming-Yue
    Jin, Xue-Jun
    Zheng, Chang-Ji
    Piao, Hu-Ri
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 295 - 306
  • [44] Synthesis and Evaluation of Selected Benzimidazole Derivatives as Potential Antimicrobial Agents
    Alasmary, Fatmah A. S.
    Snelling, Anna M.
    Zain, Mohammed E.
    Alafeefy, Ahmed M.
    Awaad, Amani S.
    Karodia, Nazira
    MOLECULES, 2015, 20 (08) : 15206 - 15223
  • [45] Design and synthesis of some azole derivatives as potential antimicrobial agents
    Deniz Sahin
    Hacer Bayrak
    Ahmet Demirbas
    Neslihan Demirbas
    Sengul Alpay-Karaoglu
    Medicinal Chemistry Research, 2012, 21 : 4485 - 4498
  • [46] Design and synthesis of some azole derivatives as potential antimicrobial agents
    Sahin, Deniz
    Bayrak, Hacer
    Demirbas, Ahmet
    Demirbas, Neslihan
    Alpay-Karaoglu, Sengul
    MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (12) : 4485 - 4498
  • [47] SYNTHESIS OF CERTAIN THIOSEMICARBAZIDE AND TRIAZOLE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS
    ASHOUR, FA
    ALMAZROA, SA
    FARMACO, 1990, 45 (11): : 1207 - 1218
  • [48] Synthesis and Antimicrobial Studies of Some Novel Pyrazoline and Isoxazoline Derivatives
    Jadhav, S. B.
    Shastri, R. A.
    Gaikwad, K. V.
    Gaikwad, S. V.
    E-JOURNAL OF CHEMISTRY, 2009, 6 : S183 - S188
  • [49] Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents
    Kamal, Ahmed
    Reddy, J. Surendranadha
    Ramaiah, M. Janaki
    Dastagiri, D.
    Bharathi, E. Vijaya
    Azhar, M. Ameruddin
    Sultana, Farheen
    Pushpavalli, S. N. C. V. L.
    Pal-Bhadra, Manika
    Juvekar, Aarti
    Sen, Subrata
    Zingde, Surekha
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (09) : 3924 - 3937
  • [50] Synthesis and antiproliferative activity of benzocyclobutacarbazol derivatives.: A new class of potential antitumor agents
    Graf-Christophe, S
    Kuehm-Caubère, C
    Renard, P
    Pfeiffer, B
    Pierré, A
    Léonce, S
    Caubère, P
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (23) : 2589 - 2591
12345