Synthesis of New Class of Spirochromanone/Isoxazole/Isoxazoline Derivatives as Potential Antimicrobial Agents

被引：0
|
作者：
Raju, M. [1 ,2 ]
Hemasri, Y. [1 ]
Rao, Y. Jayaprakash [3 ]
机构：
[1] Osmania Univ, Dept Chem, Nizam Coll, Hyderabad 500001, India
[2] Govt Degree Coll, Alair 508101, India
[3] Osmania Univ, Univ Coll Sci Saifabad, Dept Chem, Hyderabad 500004, India
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2024年 / 94卷 / 09期
关键词：
spirochromanone; 1,3-dipolar cycloaddition; chromanone; isoxazole; isooxazoline; ANTIOXIDANT ACTIVITY; ISOXAZOLINES; ANTICANCER; DESIGN;
D O I：
10.1134/S107036322409024X
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AbstractA series of novel hybrid derivatives of spirochromanone and isoxazole/isoxazoline was synthesized by 1,3-dipolar cycloaddition of the corresponding spirochromanone alkyne/alkene with nitrile oxides, in situ generated from substituted oximes in the presence of eco-friendly oxidant (sodium hypochlorite) under mild reaction conditions. All new compounds were structurally characterized by 1H, 13C NMR and HRMS techniques. All synthesized compounds were evaluated for their antimicrobial and antifungal activities.
引用
收藏
页码：2460 / 2469
页数：10
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