Directed nucleophilic aromatic substitution reaction

被引：0

作者：

Nitta, Yasuyuki ^{[1
]}

Nakashima, Yusei ^{[1
]}

Sumimoto, Michinori ^{[1
]}

Nishikata, Takashi ^{[1
]}

机构：

[1] Yamaguchi Univ, Grad Sch Sci & Engn, 2-16-1 Tokiwadai, Ube, Yamaguchi 7558611, Japan

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 96期

关键词：

CROSS-COUPLING REACTIONS; DEOXYFLUORINATION; HALIDES; AMINE;

D O I：

10.1039/d4cc04912h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, we discovered a directed nucleophilic aromatic substitution reaction, "directed SNAr (dSNAr)," in the reaction of ortho-iodobezamides and amine in the presence of pyridine. The reaction proceeded ortho-specifically and did not require a strong electron-withdrawing group on the arene substrate. Most reactions proceeded at room temperature in the presence of Py, and a wide range of amine nucleophiles can be applied. Furthermore, the reactions with benzamide substituted with multiple halogens were found to be 100% ortho-selective.

引用

页码：14284 / 14287

页数：4

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