Directed nucleophilic aromatic substitution reaction

被引：0
|
作者：
Nitta, Yasuyuki [1 ]
Nakashima, Yusei [1 ]
Sumimoto, Michinori [1 ]
Nishikata, Takashi [1 ]
机构：
[1] Yamaguchi Univ, Grad Sch Sci & Engn, 2-16-1 Tokiwadai, Ube, Yamaguchi 7558611, Japan
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 96期
关键词：
CROSS-COUPLING REACTIONS; DEOXYFLUORINATION; HALIDES; AMINE;
D O I：
10.1039/d4cc04912h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, we discovered a directed nucleophilic aromatic substitution reaction, "directed SNAr (dSNAr)," in the reaction of ortho-iodobezamides and amine in the presence of pyridine. The reaction proceeded ortho-specifically and did not require a strong electron-withdrawing group on the arene substrate. Most reactions proceeded at room temperature in the presence of Py, and a wide range of amine nucleophiles can be applied. Furthermore, the reactions with benzamide substituted with multiple halogens were found to be 100% ortho-selective.
引用
收藏
页码：14284 / 14287
页数：4
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