Lighting up Mycobacteria with membrane-targeting peptides

被引：0

作者：

Alghamdi, Zainab S. ^{[1
,2
]}

Sharma, Richa ^{[1
]}

Kiruthiga, Nancy ^{[3
]}

Ucuncu, Muhammed ^{[1
,4
]}

Klausen, Maxime ^{[1
]}

Santra, Mithun ^{[1
]}

Devi, Uma ^{[3
]}

Venkateswaran, Seshasailam ^{[5
]}

Lilienkampf, Annamaria ^{[1
]}

Bradley, Mark ^{[5
]}

机构：

[1] Univ Edinburgh, Sch Chem, David Brewster Rd, Edinburgh EH9 3FJ, Scotland

[2] Imam Abdulrahman Bin Faisal Univ, Coll Sci, Dept Chem, POB 1982, Dammam 31441, Saudi Arabia

[3] Indian Council Med Res ICMR, Natl Inst Res TB, 1 Mayor Sathiyamoorthy Rd, Chennai 600031, India

[4] Izmir Katip Celebi Univ, Fac Pharm, Dept Analyt Chem, Izmir, Turkiye

[5] Queen Mary Univ London, Precis Healthcare Univ Res Inst, Empire House, London E1 1HH, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 44期

基金：

欧盟地平线“2020”;

关键词：

RED;

D O I：

10.1039/d4ob01333f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a series of fluorescent probes based on mycobacteria membrane-associated disruption peptide, containing either L- or D-amino acids which were originally designed to kill Mycobacterium tuberculosis via membrane disruption. These peptides were decorated with "always on" and environmentally sensitive fluorophores and showed the rapid and efficient labelling of Mycobacterium smegmatis, with labelling of Mycobacterium tuberculosis demonstrated by two of the probes.

引用

页码：8781 / 8786

页数：6

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