Lighting up Mycobacteria with membrane-targeting peptides

被引：0

作者：

Alghamdi, Zainab S. ^{[1
,2
]}

Sharma, Richa ^{[1
]}

Kiruthiga, Nancy ^{[3
]}

Ucuncu, Muhammed ^{[1
,4
]}

Klausen, Maxime ^{[1
]}

Santra, Mithun ^{[1
]}

Devi, Uma ^{[3
]}

Venkateswaran, Seshasailam ^{[5
]}

Lilienkampf, Annamaria ^{[1
]}

Bradley, Mark ^{[5
]}

机构：

[1] Univ Edinburgh, Sch Chem, David Brewster Rd, Edinburgh EH9 3FJ, Scotland

[2] Imam Abdulrahman Bin Faisal Univ, Coll Sci, Dept Chem, POB 1982, Dammam 31441, Saudi Arabia

[3] Indian Council Med Res ICMR, Natl Inst Res TB, 1 Mayor Sathiyamoorthy Rd, Chennai 600031, India

[4] Izmir Katip Celebi Univ, Fac Pharm, Dept Analyt Chem, Izmir, Turkiye

[5] Queen Mary Univ London, Precis Healthcare Univ Res Inst, Empire House, London E1 1HH, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 44期

基金：

欧盟地平线“2020”;

关键词：

RED;

D O I：

10.1039/d4ob01333f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a series of fluorescent probes based on mycobacteria membrane-associated disruption peptide, containing either L- or D-amino acids which were originally designed to kill Mycobacterium tuberculosis via membrane disruption. These peptides were decorated with "always on" and environmentally sensitive fluorophores and showed the rapid and efficient labelling of Mycobacterium smegmatis, with labelling of Mycobacterium tuberculosis demonstrated by two of the probes.

引用

页码：8781 / 8786

页数：6

共 50 条

[21] LIR motifs and the membrane-targeting domain are complementary in the function of RavZ
Park, Sang-Won
Jun, Yong-Woo
Jeon, Pureum
Lee, You-Kyung
Park, Ju-Hui
Lee, Seung-Hwan
Lee, Jin-A
Jang, Deok-Jin
BMB REPORTS, 2019, 52 (12) : 700 - 705
[22] Superdiffusive motion of membrane-targeting C2 domains
Campagnola, Grace
Nepal, Kanti
Schroder, Bryce W.
Peersen, Olve B.
Krapf, Diego
SCIENTIFIC REPORTS, 2015, 5
[23] Regulation of protein kinase C's membrane interaction by two membrane-targeting domains?
Newton, AC
BIOPHYSICAL JOURNAL, 1997, 72 (02) : TUP88 - TUP88
[24] DETERMINANTS OF MEMBRANE-TARGETING AND TRANSMEMBRANE TRANSLOCATION DURING BACTERIAL PROTEIN EXPORT
SWIDERSKY, UE
HOFFSCHULTE, HK
MULLER, M
EMBO JOURNAL, 1990, 9 (06): : 1777 - 1785
[25] Membrane-Targeting Approaches for Enhanced Cancer Cell Destruction with Irreversible Electroporation
Jiang, Chunlan
Qin, Zhenpeng
Bischof, John
ANNALS OF BIOMEDICAL ENGINEERING, 2014, 42 (01) : 193 - 204
[26] Structure of a mitochondrial ribosome with fragmented rRNA in complex with membrane-targeting elements
Victor Tobiasson
Ieva Berzina
Alexey Amunts
Nature Communications, 13
[27] Membrane-Targeting Approaches for Enhanced Cancer Cell Destruction with Irreversible Electroporation
Chunlan Jiang
Zhenpeng Qin
John Bischof
Annals of Biomedical Engineering, 2014, 42 : 193 - 204
[28] Structure of a mitochondrial ribosome with fragmented rRNA in complex with membrane-targeting elements
Tobiasson, Victor
Berzina, Ieva
Amunts, Alexey
NATURE COMMUNICATIONS, 2022, 13 (01)
[29] Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain
Hamada, K
Shimizu, T
Matsui, T
Tsukita, S
Tsukita, S
Hakoshima, T
EMBO JOURNAL, 2000, 19 (17): : 4449 - 4462
[30] 5-Alkyloxytryptamines are membrane-targeting, broad-spectrum antibiotics
Faulkner, Katherine C.
Hurley, Katherine A.
Weibel, Douglas B.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (22) : 5539 - 5544

← 1 2 3 4 5 →