Investigation of myocardial lipid peroxidation and myocardial enzyme activity under acute hypobaric hypoxia

被引：0
|
作者：
Li, Qingdi [1 ]
Yang, Ye [1 ]
Yu, Qifu [1 ]
Hao, Weiwei [1 ]
Qin, Suqing [1 ]
机构：
[1] Naval General Hospital, Beijing, China
来源：
Hangtian Yixue Yu Yixue Gongcheng/Space Medicine and Medical Engineering | 1994年 / 7卷 / 03期
关键词：
Enzyme kinetics - Free radicals - Lipids - Muscle - Oxygen - Peroxides - Tissue;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this paper, SeGSHpx, MDA content, SeGSHpx/MDA ratio and several kinds of myocardial enzymes such as CPK, CK-MB, LDH, α-HBD and AST were measured in 39 healthy adult Wistar rats staying at 7500m for 30min in a hypobaric chamber in order to observe the effect of acute hypoxia upon the myocardium and the relationship between lipid peroxidation and myocardial damage. The results showed that activity of myocardial enzymes was raised significantly after acute hypoxia, the difference was remarkable as compared with the control values (P<0.01 or 0.001). Acute hypobaric hypoxia had also some influences on the myocardial SeGSHpx activity, MDA content, and SeGSHpx/MDA ratio.
引用
收藏
页码：181 / 185
相关论文
共 50 条
  • [21] Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats
    Xu, Wei-Qing
    Yu, Zhuo
    Xie, Yan
    Huang, Guo-Qian
    Shu, Xian-Hong
    Zhu, Yi
    Zhou, Zhao-Nian
    Yang, Huang-Tian
    BASIC RESEARCH IN CARDIOLOGY, 2011, 106 (03) : 329 - 342
  • [22] Changes in Lipid Peroxidation in the Hippocampus and Neocortex after Severe Hypobaric Hypoxia in Rats
    Kislin, M. S.
    Tyul'kova, E. I.
    Samoilov, M. O.
    NEUROCHEMICAL JOURNAL, 2009, 3 (03) : 184 - 190
  • [23] Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats
    Wei-Qing Xu
    Zhuo Yu
    Yan Xie
    Guo-Qian Huang
    Xian-Hong Shu
    Yi Zhu
    Zhao-Nian Zhou
    Huang-Tian Yang
    Basic Research in Cardiology, 2011, 106 : 329 - 342
  • [24] EFFECTS OF PROTEIN-SYNTHESIS INHIBITORS ON MYOCARDIAL HYPERTROPHY DUE TO ACUTE HYPOBARIC HYPOXIA IN RATS
    GENOVESE, A
    POLVERINO, W
    CACCIAPUOTI, AA
    CONDORELLI, M
    MINERVA CARDIOANGIOLOGICA, 1979, 27 (09): : 547 - 550
  • [25] Cardiac Enzymes, Total Thiols And Lipid Peroxidation In Patients With Acute Myocardial Infarction
    Suresh, Babu
    Shetty, Jeevan Kumar
    Prakash, Mungli
    JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2010, 4 (06) : 3425 - 3429
  • [26] Iron status and its relationship with lipid peroxidation in patients with acute myocardial infarction
    Baykan, M
    Çelik, S
    Örem, A
    Malkoç, M
    Erdöl, C
    Baykan, EC
    Örem, C
    Karahan, B
    ACTA CARDIOLOGICA, 2001, 56 (05) : 277 - 281
  • [27] LIPID-PEROXIDATION DURING MYOCARDIAL REPERFUSION
    CECONI, C
    CARGNONI, A
    PASINI, E
    CONDORELLI, E
    CURELLO, S
    FERRARI, R
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 1992, 111 (1-2) : 49 - 54
  • [28] Role of lipid peroxidation in myocardial ischemic injury
    West, M
    Srivastava, S
    Bhatnagar, A
    MYOCARDIAL ISCHEMIA AND PRECONDITIONING, 2003, 6 : 465 - 480
  • [29] MYOCARDIAL LDH ISOENZYME PATTERNS IN RATS EXPOSED TO COLD AND OR HYPOBARIC HYPOXIA
    KAAJA, R
    ARE, K
    ACTA MEDICA SCANDINAVICA, 1982, : 136 - 142
  • [30] ELECTROCARDIOGRAPHIC CHANGES IN RATS UNDER ACUTE HYPOBARIC HYPOXIA
    PONCEZUMINO, A
    SALDENA, TA
    AGUERO, E
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1981, 14 (06) : 439 - 439
12345