Recent progress in asymmetric radical reactions enabled by chiral iron catalysts

Transition-metal-catalyzed radical asymmetric reactions offer a versatile and effective platform for accessing chiral organic molecules with high enantiopurity. Given that iron is the most abundant and less toxic transition metalic element available, the application of iron catalysts is considered to be a more sustainable and attractive approach. Over the last decade, several exciting and notable achievements have been witnessed. In this highlight, we aim to provide an overview of the progress in ligand-enabled iron-catalyzed asymmetric radical reactions, with an emphasis on the reaction mechanisms. In this highlight, we discuss recently developed chiral iron catalysts and their application in radical asymmetric reactions for the construction of axial or central chirality.