Asymmetric Carbonyl-ene Reactions Promoted by Chiral Catalysts

被引：1

作者：

Zhang Yongli ^{[1
]}

Zhang Rui ^{[1
]}

Chang Honghong ^{[1
]}

Wei Wenlong ^{[1
]}

Li Xing ^{[1
]}

机构：

[1] Taiyuan Univ Technol, Coll Chem & Chem Engn, Taiyuan 030024, Peoples R China

来源：

PROGRESS IN CHEMISTRY | 2014年 / 26卷 / 09期

关键词：

homoallylic alcohols; carbonyl-ene; asymmetric catalysis; chiral organometallic catalysts; chiral organic molecular catalysts; FRIEDEL-CRAFTS REACTIONS; FLEXIBLE NUPHOS DIPHOSPHINES; ALPHA-HYDROXY ESTERS; LEWIS-ACID; ENANTIOSELECTIVE ALLYLATION; EFFICIENT CATALYSTS; BIS(((S)-BINAPHTHOXY)(ISOPROPOXY)TITANIUM) OXIDE; PALLADIUM(II) COMPLEXES; IN(III)-PYBOX COMPLEX; GLYOXYLATE;

D O I：

10.7536/PC140319

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral homoallylic alcohols are important drug intermediates for synthesis of pharmaceutical molecules and nature products. Asymmetric carbonyl-ene reaction is a powerful tool for the preparation of them. The chiral catalysts reported include chiral organometallic complexs and chiral organic molecules, which have achieved good catalytic activity and enantioselectivity. This paper reviews the application of various types of chiral catalysts in asymmetric carbonyl-ene reactions, the reaction mechanism of asymmetric induction, the effect of the structure of the catalysts and reaction conditions on the catalytic activity and enantioselectivity.

引用

页码：1492 / 1505

页数：14

共 51 条

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