Recent advancements in microfluidic-based biosensors for detection of genes and proteins: Applications and techniques

被引：0
|
作者：
Siavashy S. [1 ]
Soltani M. [1 ,2 ,3 ,4 ]
Rahimi S. [5 ]
Hosseinali M. [6 ]
Guilandokht Z. [7 ]
Raahemifar K. [8 ,9 ,10 ]
机构：
[1] Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran
[2] Department of Electrical and Computer and Engineering, University of Waterloo, Waterloo
[3] Centre for Biotechnology and Bioengineering (CBB), University of Waterloo, Waterloo
[4] Centre for Sustainable Business, International Business University, Toronto
[5] Mork Family Department of Chemical Engineering and Material Science, University of Southern California, Los Angeles
[6] School of Pharmacy٫ Faculty of Science, University of Waterloo, Waterloo, Ontario, Canada, 200 University Avenue West, Waterloo, N2L 3G1, ON
[7] Department of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran
[8] Data Science and Artificial Intelligence Program College of Information Sciences and Technology (IST), Penn State UniversityStateCollege, 16801, PA
[9] School of Optometry and Vision Science, Faculty of Science, University of Waterloo, 200 University Ave. W, Waterloo, N2L 3G1, ON
[10] Department of Chemical Engineering, Faculty of Engineering, University of Waterloo, 200 University Ave. W, Waterloo, N2L 3G1, ON
来源：
Biosensors and Bioelectronics: X | 2024年 / 19卷
关键词：
Biosensors; ELISA; Lab on a chip; Microfluidics; PCR; Western blotting;
D O I：
10.1016/j.biosx.2024.100489
中图分类号：
学科分类号：
摘要：
This article has tried to provide an overview of the most sophisticated microfluidic biosensors for identifying nucleic acids and proteins at the site of treatment. Microfluidics, which also automates sample preparation and reduces processing time and reagent consumption, enables the analysis of small sample quantities. Microfluidics and biosensor technologies collaborate to provide diagnostics at the point of care with high throughput analysis, portability, and disposability. The high sensitivity and selectivity requirements, false response errors, and integration with other essential modules are some of the challenges posed by this merger. The broad categories of protein-based and DNA-based biosensor technology are covered in this review. Also, recent advancements in coupling the biosensors to microfluidics, the main challenges and potential solutions in deploying microfluidic biosensors for point-of-care diagnostics, and the most recent developments in these areas have been discussed. © 2024
引用
收藏
相关论文
共 50 条
  • [41] Towards microfluidic-based exosome isolation and detection for tumor therapy
    Wang, Jie
    Ma, Peng
    Kim, Daniel H.
    Liu, Bi-Feng
    Demirci, Utkan
    NANO TODAY, 2021, 37
  • [42] Recent Advances in Aptamer-Based Microfluidic Biosensors for the Isolation, Signal Amplification and Detection of Exosomes
    Hu, Jessica
    Gao, Dan
    SENSORS, 2025, 25 (03)
  • [43] Advancements in Nanofiber-Based Electrochemical Biosensors for Diagnostic Applications
    Iftikhar, Faiza Jan
    Shah, Afzal
    Wali, Qamar
    Kokab, Tayyaba
    BIOSENSORS-BASEL, 2023, 13 (04):
  • [44] An insight to the recent advancements in detection of Mycobacterium tuberculosis using biosensors: A systematic review
    Chaturvedi, Mansi
    Patel, Monika
    Tiwari, Archana
    Dwivedi, Neeraj
    Mondal, D. P.
    Srivastava, Avanish Kumar
    Dhand, Chetna
    PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2024, 186 : 14 - 27
  • [45] Recent advances in microfluidic chip integrated electronic biosensors for multiplexed detection
    Liao, Zerong
    Wang, Jianfeng
    Zhang, Pengjie
    Zhang, Yang
    Miao, Yunfei
    Gao, Shimeng
    Deng, Yulin
    Geng, Lina
    BIOSENSORS & BIOELECTRONICS, 2018, 121 : 272 - 280
  • [46] Advancements in low light image enhancement techniques and recent applications
    Anoop, P. P.
    Deivanathan, R.
    JOURNAL OF VISUAL COMMUNICATION AND IMAGE REPRESENTATION, 2024, 103
  • [47] Recent strategies toward microfluidic-based surface-enhanced Raman spectroscopy
    Tycova, Anna
    Prikryl, Jan
    Foret, Frantisek
    ELECTROPHORESIS, 2017, 38 (16) : 1977 - 1987
  • [48] Modeling and simulation of DNA flow in a microfluidic-based pathogen detection system
    Trebotich, D
    Miller, GH
    2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology, 2005, : 353 - 355
  • [49] Advancements in microRNA-based electrochemical biosensors for preeclampsia detection
    Ameya, K. P.
    Sekar, Durairaj
    HYPERTENSION RESEARCH, 2024, 47 (06) : 1752 - 1754
  • [50] Design optimization of microfluidic-based solvent extraction systems for radionuclides detection
    Pineda, M.
    Tsaoulidis, D.
    Filho, P.I.O.
    Tsukahara, T.
    Angeli, P.
    Fraga, E.S.
    Nuclear Engineering and Design, 2021, 383
12345