Recent advancements in microfluidic-based biosensors for detection of genes and proteins: Applications and techniques

被引：0
|
作者：
Siavashy S. [1 ]
Soltani M. [1 ,2 ,3 ,4 ]
Rahimi S. [5 ]
Hosseinali M. [6 ]
Guilandokht Z. [7 ]
Raahemifar K. [8 ,9 ,10 ]
机构：
[1] Department of Mechanical Engineering, K. N. Toosi University of Technology, Tehran
[2] Department of Electrical and Computer and Engineering, University of Waterloo, Waterloo
[3] Centre for Biotechnology and Bioengineering (CBB), University of Waterloo, Waterloo
[4] Centre for Sustainable Business, International Business University, Toronto
[5] Mork Family Department of Chemical Engineering and Material Science, University of Southern California, Los Angeles
[6] School of Pharmacy٫ Faculty of Science, University of Waterloo, Waterloo, Ontario, Canada, 200 University Avenue West, Waterloo, N2L 3G1, ON
[7] Department of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran
[8] Data Science and Artificial Intelligence Program College of Information Sciences and Technology (IST), Penn State UniversityStateCollege, 16801, PA
[9] School of Optometry and Vision Science, Faculty of Science, University of Waterloo, 200 University Ave. W, Waterloo, N2L 3G1, ON
[10] Department of Chemical Engineering, Faculty of Engineering, University of Waterloo, 200 University Ave. W, Waterloo, N2L 3G1, ON
来源：
Biosensors and Bioelectronics: X | 2024年 / 19卷
关键词：
Biosensors; ELISA; Lab on a chip; Microfluidics; PCR; Western blotting;
D O I：
10.1016/j.biosx.2024.100489
中图分类号：
学科分类号：
摘要：
This article has tried to provide an overview of the most sophisticated microfluidic biosensors for identifying nucleic acids and proteins at the site of treatment. Microfluidics, which also automates sample preparation and reduces processing time and reagent consumption, enables the analysis of small sample quantities. Microfluidics and biosensor technologies collaborate to provide diagnostics at the point of care with high throughput analysis, portability, and disposability. The high sensitivity and selectivity requirements, false response errors, and integration with other essential modules are some of the challenges posed by this merger. The broad categories of protein-based and DNA-based biosensor technology are covered in this review. Also, recent advancements in coupling the biosensors to microfluidics, the main challenges and potential solutions in deploying microfluidic biosensors for point-of-care diagnostics, and the most recent developments in these areas have been discussed. © 2024
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