Theoretical considerations on immediate interactions between inhaled particles and the pulmonary surfactant

被引：0
|
作者：
Sosnowski, Tomasz R. [1 ,2 ]
Gradoń, Leon [1 ]
Podgórski, Albert [1 ]
机构：
[1] Department of Chemical and Process Engineering, Warsaw University of Technology, ul. Warynskiego 1, 00-645Warsaw, Poland
[2] Lovelace Respiratory Research Institute, Albuquerque, NM 87185, United States
来源：
Journal of Aerosol Science | 2000年 / 31卷 / SUPPL. 1期
关键词：
Adsorption - Aerosols - Hydrophobicity - Particle size analysis - Porosity - Pulmonary diseases - Respiratory mechanics - Surface active agents - Surface tension - Wetting;
D O I：
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摘要：
The interactions between freshly deposited airborne particles and the pulmonary surfactant (PS) are analyzed. Due to effective sorption of PS components at hydrophobic surfaces, hydrophobic (HB) particles become better wetted by the hypophase. In addition, both HB and hydrophilic (HL) particles can induce a similar immediate hydrodynamic response at the air/liquid interface. It is likely that a superficial microflow towards the spot of particle deposition can be recognized by alveolar macrophages as a first signal of the presence of foreign body on the alveolar surface.
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