Progress in the Research of Synthetic Biology in Construction of Engineered Microorganisms

被引：1
|
作者：
Gao X. [1 ]
Liu Y. [1 ]
Jiang Z. [1 ]
Zeng Q. [1 ]
Liu S. [1 ]
Liu X. [1 ]
Min W. [1 ]
机构：
[1] National Engineering Laboratory on Wheat and Corn Further Processing, College of Food Science and Engineering, Jilin Agricultural University, Changchun
来源：
Shipin Kexue/Food Science | 2022年 / 43卷 / 15期
关键词：
Construction of engineered microorganisms; Genome editing; Metabolic regulation; Synthetic biology;
D O I：
10.7506/spkx1002-6630-20210831-414
中图分类号：
学科分类号：
摘要：
As a new interdisciplinary subject that covers many fields in the 21st century, synthetic biology is of great help in exploring the basic laws of life activities and biotechnological innovations and breakthroughs. Synthetic biotechnology is a new approach to construct engineered microorganisms. It has been widely used to produce amino acids, organic acids, aromatic compounds, sugars, and so on. The yield of target products produced by recombinant engineered microorganisms can be efficiently increased by using advanced modules, systematic design and new genome editing methods to engineer the complex metabolic pathways in type strains, promoting the rapid development of social productivity. In this paper, the latest advances in the application of synthetic biology for the construction of engineered microorganism are reviewed, the developmental course of synthetic biotechnology is elaborated, and its application for the construction of engineered microorganism is exemplified. With the deepening of research on engineered microorganisms, synthetic biotechnology will bring new breakthroughs and opportunities for the fermentation industry. © 2022, China Food Publishing Company. All right reserved.
引用
收藏
页码：256 / 264
页数：8
相关论文
共 54 条
  • [41] LIU Long, LI Jianghua, JUN Fang, Et al., Process modeling and optimization of whole-cell biotransformation synthesis of α-ketoisocaproate by Bacillus cereus producing branched-chain amino acid aminotransferase with artificial neural network coupling genetic algorithm, Journal of Bioscience, 108, 1, pp. S127-S128, (2009)
  • [42] (2018)
  • [43] (2020)
  • [44] SONG Yang, LI Jianghua, SHIN H D, Et al., Tuning the transcription and translation of L-amino acid deaminase in Escherichia coli improves α-ketoisocaproate production from L-leucine, PLoS ONE, 12, 6, (2017)
  • [45] 30, 1, (2021)
  • [46] PADDON C J, WESTFALL P J, PITERA D J, Et al., High-level semisynthetic production of the potent antimalarial artemisinin, Nature, 496, pp. 528-532, (2013)
  • [47] BIAN Guangkai, HOU Anwei, YUAN Yujie, Et al., Metabolic engineering-based rapid characterization of a sesquiterpene cyclase and the skeletons of fusariumdiene and fusagramineol from Fusarium graminearum, Organic Letters, 20, 6, pp. 1626-1629, (2018)
  • [48] ZHOU Yongjin, GAO Wei, RONG Qixian, Et al., Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production, Journal of the American Chemical Society, 134, 6, pp. 3234-3241, (2012)
  • [49] DAI Zhubo, WANG Beibei, LIU Yi, Et al., Producing aglycons of ginsenosides in bakers' yeast, Scientific Reports, 4, 1, pp. 689-699, (2014)
  • [50] YAMANAKA K, REYNOLDS K A, KERSTEN R D, Et al., Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A, Proceedings of the National Academy of Sciences, 111, 5, pp. 1957-1962, (2014)
123456