Transition-metal-free direct nucleophilic substitution of carboranyllithium and 2-halopyridines

被引：15
|
作者：
Lu J.-Y. [1 ,2 ]
Zhao B. [2 ]
Du Y. [2 ]
Yang J. [1 ]
Lu J. [1 ,2 ]
机构：
[1] Laboratory of Green Catalysis and Reaction Engineering of Haikou, Hainan Provincial Fine Chemical Engineering Research Center, School of Sciences, Hainan University, Haikou
[2] State Key Laboratory of Fluorine and Nitrogen Chemicals, Xi'An Modern Chemistry Research Institute, Xi'an Shaanxi
来源：
Organic and Biomolecular Chemistry | 2019年 / 17卷 / 32期
基金：
中国国家自然科学基金;
关键词：
Transition metals;
D O I：
10.1039/c9ob00978g
中图分类号：
学科分类号：
摘要：
A practical and efficient C(cage)-heteroarylation of carborane is presented, via direct nucleophilic substitution of carboranyllithium with 2-halopyridines. This reaction does not need the aid of any transition metal and utilizes readily available carboranyllithium nucleophiles, thereby avoiding transmetalation of carboranyllithium. The process exhibits a broad scope, and a vast array of 2-halopyridines have proven to be suitable substrates. The method serves as a complement to C(cage)-arylation reactions and may find wide applications in materials science and medicinal and coordination chemistry. © 2019 The Royal Society of Chemistry.
引用
收藏
页码：7438 / 7441
页数：3
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