Transition-Metal-Free Diarylation of Isocyanates with Arynes

被引：4
|
作者：
Jang, Woo Cheol [1 ]
Hwang, Dong Wook [1 ]
Seo, Jeong Hoon [1 ]
Ko, Haye Min [1 ]
机构：
[1] Wonkwang Univ, Dept Bionano Chem, 460 lksandae Ro, Iksan 54538, Jeonbuk, South Korea
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 38期
基金：
新加坡国家研究基金会;
关键词：
Transition-metal-free; Isocyanate; Aryne; Diarylation; FACILE N-ARYLATION; PALLADIUM-CATALYZED AMINATION; BOND-FORMING REACTIONS; HETEROCYCLIC CARBENE; ARYL CHLORIDES; DERIVATIVES; AMINES; DIPHENYLAMINE; BROMIDES; HETEROARYL;
D O I：
10.1016/j.tetlet.2019.151018
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile method for the transition-metal-free diarylation of isocyanates with arynes in the presence of cesium fluoride has been developed, which affords functionalized diaryl amines in moderate to excellent yields. This reaction has good functional group tolerance and provides excellent regioselectivity by utilizing a methoxy-substituted aryne precursor. (C) 2019 Elsevier Ltd. All rights reserved.
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页数：4
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