Biomimetic selenium nanosystems for infectious wound healing

Bacteria-related wound infection and healing have been a major issue for patients and health-care systems for decades. The rise and evolution of effective treatment will result in significant benefits to human beings. In addition to standard antibacterial drugs, a combination of nanoparticles (NPs) and biological membranes is widely applied as a novel antibacterial agent against infectious pathogens. In this paper, the red blood cell membrane-encapsulated selenium nanoparticles (R-SeNPs) were fabricated for infectious wound healing. The stability, the immune evading capability, and the internal circulation time of the R-SeNPs were notably enhanced compared with those of bare selenium nanoparticles (SeNPs). Moreover, in vivo studies demonstrated the outstanding performance of the R-SeNPs in infectious wound healing. The biomimetic selenium nanosystem demonstrated the benefits of the combination of nanotechnology and bionics design and will contribute to wound healing in the future. © 2023