Introduction of Carbon Substituents into Nitroarenes via Nucleophilic Substitution of Hydrogen: New Developments

Nucleophilic substitution of hydrogen in nitroarenes has become a powerful synthetic tool for functionalization of these important organic substrates, complementary to other modern methods. In this review we present new developments in the area of introduction of alkyl and functionalized alkyl substituents into nitroarene rings via nucleoÂ-philic substitution of hydrogen, followed by application of these processes in the construction of carbo- A nd heterocyclic rings. Finally, new developments in the investigation of the mechanism of S N ArH are summarized. 1 Introduction 2 Alkylation and Haloalkylation 3 Functionalized Carbon Substituents 4 Formation of Carbo- A nd Heterocyclic Rings 5 Mechanistic Aspects of S N ArH 6 Conclusion. © 2020 Thieme. All rights reserved.