Structure-activity relationships and mechanisms of triterpenoids against virus

被引：0
|
作者：
Fan B. [1 ]
Wang Y. [1 ]
Lian X. [1 ]
Xie W. [1 ]
Yu Y. [1 ]
Liang J. [1 ]
机构：
[1] School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing
来源：
Huagong Xuebao/CIESC Journal | 2020年 / 71卷 / 09期
关键词：
Anti-virus; Mechanism; Structure-activity relationship; Triterpenoids;
D O I：
10.11949/04381157.20200495
中图分类号：
学科分类号：
摘要：
Triterpenoids are widely present in nature and have received wide attention because of their anti-tumor, anti-viral, antibacterial, anti-inflammatory and immunomodulatory pharmacological activities. The compounds such as oleanolic acid, ursolic acid, glycyrrhizic acid and betulinic acid in natural triterpenes all showed good anti-viral activity. This review summarizes the advances of triterpenoids and their derivatives exemplified by tetracyclic triterpenes and pentacyclic triterpenes, and focusses on the structure-activity relationships and mechanisms of anti-HIV, anti-influenza, anti-coronavirus and anti-HBV/HCV. Thus, it would provide clues for rational design and development of novel anti-viral agents for the future. © 2020, Chemical Industry Press Co., Ltd. All right reserved.
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页码：4071 / 4101
页数：30
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