Structure-activity relationships and mechanisms of triterpenoids against virus

被引：0
|
作者：
Fan B. [1 ]
Wang Y. [1 ]
Lian X. [1 ]
Xie W. [1 ]
Yu Y. [1 ]
Liang J. [1 ]
机构：
[1] School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing
来源：
Huagong Xuebao/CIESC Journal | 2020年 / 71卷 / 09期
关键词：
Anti-virus; Mechanism; Structure-activity relationship; Triterpenoids;
D O I：
10.11949/04381157.20200495
中图分类号：
学科分类号：
摘要：
Triterpenoids are widely present in nature and have received wide attention because of their anti-tumor, anti-viral, antibacterial, anti-inflammatory and immunomodulatory pharmacological activities. The compounds such as oleanolic acid, ursolic acid, glycyrrhizic acid and betulinic acid in natural triterpenes all showed good anti-viral activity. This review summarizes the advances of triterpenoids and their derivatives exemplified by tetracyclic triterpenes and pentacyclic triterpenes, and focusses on the structure-activity relationships and mechanisms of anti-HIV, anti-influenza, anti-coronavirus and anti-HBV/HCV. Thus, it would provide clues for rational design and development of novel anti-viral agents for the future. © 2020, Chemical Industry Press Co., Ltd. All right reserved.
引用
收藏
页码：4071 / 4101
页数：30
相关论文
共 128 条
  • [91] Ryu Y B, Park S J, Kim Y M, Et al., SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii, Bioorganic & Medicinal Chemistry Letters, 20, 6, pp. 1873-1876, (2010)
  • [92] Lin C M, Wang G M, Jow J M, Et al., Functional analysis of hepatitis B virus pre-S deletion variants associated with hepatocellular carcinoma, Journal of Biomedical Science, 19, (2012)
  • [93] Li W H., The hepatitis B virus receptor, Annual Review of Cell and Developmental Biology, 31, pp. 125-147, (2015)
  • [94] Komatsu H, Inui A, Fujisawa T., Pediatric hepatitis B treatment, Journal of Thoracic Disease, 5, 3, (2017)
  • [95] Sato H, Goto W, Yamamura J I, Et al., Therapeutic basis of glycyrrhizin on chronic hepatitis B, Antiviral Research, 30, 2, pp. 171-177, (1996)
  • [96] Takahara T, Watanabe A, Shiraki K., Effects of glycyrrhizin on hepatitis B surface antigen: a biochemical and morphological study, Journal of Hepatology, 21, 4, pp. 601-609, (1994)
  • [97] Huang W, Wang W, Wang P, Et al., Glycyrrhetinic acid-functionalized degradable micelles as liver-targeted drug carrier, Journal of Materials Science. Materials in Medicine, 22, 4, pp. 853-863, (2011)
  • [98] Tian Q, Wang X H, Wang W, Et al., Insight into glycyrrhetinic acid: the role of the hydroxyl group on liver targeting, International Journal of Pharmaceutics, 400, 1, pp. 153-157, (2010)
  • [99] Wang L J, Geng C G, Ma Y B, Et al., Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents, Bioorganic & Medicinal Chemistry Letters, 22, 10, pp. 3473-3479, (2012)
  • [100] Yao D C, Li H W, Gou Y L, Et al., Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression, The FEBS Journal, 276, 9, pp. 2599-2614, (2009)
45678910111213