Immune checkpoints and pancreatic beta cell dysfunction in HIV

被引：0
|
作者：
Pryke, Luke A. [1 ]
Liu, Ziyue [1 ]
Khaitan, Alka K. [1 ]
Sims, Emily K. [1 ]
Gupta, Samir K. [1 ]
机构：
[1] Indiana Univ Sch Med, Indianapolis, IN USA
来源：
AIDS | 2024年 / 38卷 / 11期
基金：
美国国家卫生研究院;
关键词：
HELPER T-CELLS; INFECTION; TIM-3;
D O I：
10.1097/QAD.0000000000003932
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We explored the impact of immune dysregulation on pancreatic beta cell injury in HIV patients. Analyzing 105 participant samples, we observed lower IL-21 levels and elevated immune checkpoint levels (e.g. PD-1, CD27+, CD40+) in untreated HIV patients. Notably, soluble TIM-3 correlated positively with improved beta cell function and inversely with beta cell stress, suggesting its potential role in beta cell protection in untreated HIV.
引用
收藏
页码：1725 / 1727
页数：3
相关论文
共 50 条
  • [41] The effect of cholesteryl ester transfer protein on pancreatic beta cell dysfunction in mice
    Wen Guo
    Yingyun Gong
    Zhenzhen Fu
    Jinxiang Fu
    Yan Sun
    Xianxia Ju
    Yina Chang
    Wen Wang
    Xiaohui Zhu
    Beibei Gao
    Xiaoyun Liu
    Tao Yang
    Hongwen Zhou
    Nutrition & Metabolism, 13
  • [42] Hepatitis C virus infection and human pancreatic beta-cell dysfunction
    不详
    DIABETES MELLITUS, 2006, 9 (01): : 72 - 72
  • [43] The effect of cholesteryl ester transfer protein on pancreatic beta cell dysfunction in mice
    Guo, Wen
    Gong, Yingyun
    Fu, Zhenzhen
    Fu, Jinxiang
    Sun, Yan
    Ju, Xianxia
    Chang, Yina
    Wang, Wen
    Zhu, Xiaohui
    Gao, Beibei
    Liu, Xiaoyun
    Yang, Tao
    Zhou, Hongwen
    NUTRITION & METABOLISM, 2016, 13
  • [44] Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction
    Puddu, Alessandra
    Sanguineti, Roberta
    Mach, Francois
    Dallegri, Franco
    Viviani, Giorgio Luciano
    Montecucco, Fabrizio
    MEDIATORS OF INFLAMMATION, 2013, 2013
  • [45] A Novel Mediator of Arsenic-Induced Pancreatic Beta-Cell Dysfunction
    Carmean, Christopher M.
    Yokoi, Norihide
    Kirkley, Andrew G.
    Takahashi, Harumi
    Sargis, Robert M.
    Seino, Susumu
    DIABETES, 2018, 67
  • [46] INFLUENCE OF SIROLIMUS ON CYCLOSPORINE-INDUCED PANCREATIC BETA-CELL DYSFUNCTION
    Yang, Chul Woo
    Ghee, Jung Yeon
    Piao, ShangGuo
    Song, Ji Hyun
    Han, Donghe
    TRANSPLANT INTERNATIONAL, 2009, 22 : 344 - 344
  • [47] Regulation of Insulin Synthesis and Secretion and Pancreatic Beta-Cell Dysfunction in Diabetes
    Fu, Zhuo
    Gilbert, Elizabeth R.
    Liu, Dongmin
    CURRENT DIABETES REVIEWS, 2013, 9 (01) : 25 - 53
  • [48] Local biocommunication between peripancreatic adipose tissue and pancreatic beta cell: characterisation of factors involved in beta cell dysfunction
    Sidot, E.
    Guzman, C.
    Tournier, M.
    Lajoix, A. -D.
    Peraldi-Roux, S.
    DIABETOLOGIA, 2014, 57 : S306 - S306
  • [49] The prognostic and therapeutic value of the tumor microenvironment and immune checkpoints in pancreatic neuroendocrine neoplasms
    Chen, Zhijiang
    Lin, Shizhao
    Liang, Feihong
    Hou, Zelin
    Yang, Yuanyuan
    Huang, Heguang
    Pan, Yu
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [50] Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer
    Knudsen, Erik S.
    Kumarasamy, Vishnu
    Chung, Sejin
    Ruiz, Amanda
    Vail, Paris
    Tzetzo, Stephanie
    Wu, Jin
    Nambiar, Ram
    Sivinski, Jared
    Chauhan, Shailender S.
    Seshadri, Mukund
    Abrams, Scott, I
    Wang, Jianmin
    Witkiewicz, Agnieszka K.
    GUT, 2021, 70 (01) : 127 - 138
12345