Immune checkpoints and pancreatic beta cell dysfunction in HIV

被引：0

作者：

Pryke, Luke A. ^{[1
]}

Liu, Ziyue ^{[1
]}

Khaitan, Alka K. ^{[1
]}

Sims, Emily K. ^{[1
]}

Gupta, Samir K. ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Indianapolis, IN USA

来源：

AIDS | 2024年 / 38卷 / 11期

基金：

美国国家卫生研究院;

关键词：

HELPER T-CELLS; INFECTION; TIM-3;

D O I：

10.1097/QAD.0000000000003932

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We explored the impact of immune dysregulation on pancreatic beta cell injury in HIV patients. Analyzing 105 participant samples, we observed lower IL-21 levels and elevated immune checkpoint levels (e.g. PD-1, CD27+, CD40+) in untreated HIV patients. Notably, soluble TIM-3 correlated positively with improved beta cell function and inversely with beta cell stress, suggesting its potential role in beta cell protection in untreated HIV.

引用

页码：1725 / 1727

页数：3

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