Immune checkpoints and pancreatic beta cell dysfunction in HIV

被引：0
|
作者：
Pryke, Luke A. [1 ]
Liu, Ziyue [1 ]
Khaitan, Alka K. [1 ]
Sims, Emily K. [1 ]
Gupta, Samir K. [1 ]
机构：
[1] Indiana Univ Sch Med, Indianapolis, IN USA
来源：
AIDS | 2024年 / 38卷 / 11期
基金：
美国国家卫生研究院;
关键词：
HELPER T-CELLS; INFECTION; TIM-3;
D O I：
10.1097/QAD.0000000000003932
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We explored the impact of immune dysregulation on pancreatic beta cell injury in HIV patients. Analyzing 105 participant samples, we observed lower IL-21 levels and elevated immune checkpoint levels (e.g. PD-1, CD27+, CD40+) in untreated HIV patients. Notably, soluble TIM-3 correlated positively with improved beta cell function and inversely with beta cell stress, suggesting its potential role in beta cell protection in untreated HIV.
引用
收藏
页码：1725 / 1727
页数：3
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