Case report: Successful therapy with azacitidine for acute myeloid leukemia with NUP98::RARG resembling acute promyelocytic leukemia

被引：0
|
作者：
Wei, Zhichen [1 ]
Shao, Linlin [1 ]
Xu, Shuqian [1 ]
Zhang, Xiaolin [1 ]
Wang, Lin [1 ]
Qin, Ping [1 ]
Song, Qiang [1 ]
Hou, Ming [1 ,2 ]
Shi, Yan [1 ]
机构：
[1] Shandong Univ, Qilu Hosp, Dept Hematol, Jinan, Peoples R China
[2] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Shandong Prov Key Lab Immunohematol, Jinan, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词：
acute myeloid leukemia; acute promyelocytic leukemia; all-trans retinoic acid; nucleoporin 98-retinoic acid receptor gamma; azacitidine; RETINOIC ACID; FUSION;
D O I：
10.3389/fonc.2024.1460557
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report a case of acute myeloid leukemia (AML) with retinoic acid receptor gamma (RARG) rearrangement, exhibiting clinical, morphological, and immunophenotypic features similar to classic acute promyelocytic leukemia (APL). RNA sequencing analysis of the patient's bone marrow samples revealed the presence of nucleoporin 98 (NUP98)-RARG caused by translocation. AML with RARG rearrangement is insensitive to all-trans retinoic acid (ATRA) and arsenic trioxide. The patient received azacitidine therapy after failing ATRA and standard 3 + 7 therapy (idarubicin and cytarabine) and achieved complete remission. Conclusively, this acute myeloid leukemia subtype may benefit from azacitidine.
引用
收藏
页数：6
相关论文
共 50 条
  • [41] Secondary acute myeloid leukemia occurring after successful treatment of acute promyelocytic leukemia
    Junfa Chen
    Zhiyin Zheng
    Jianping Shen
    Leijun Peng
    Haifeng Zhuang
    Wenbin Liu
    Yuhong Zhou
    International Journal of Hematology, 2012, 95 : 327 - 328
  • [42] Secondary acute myeloid leukemia occurring after successful treatment of acute promyelocytic leukemia
    Chen, Junfa
    Zheng, Zhiyin
    Shen, Jianping
    Peng, Leijun
    Zhuang, Haifeng
    Liu, Wenbin
    Zhou, Yuhong
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2012, 95 (03) : 327 - 328
  • [43] RAS mutations in therapy-related acute myeloid leukemia after successful treatment of acute promyelocytic leukemia
    Kelemen, Katalin
    Kovacsovics, Tibor
    Braziel, Rita
    Corless, Christopher
    Beadling, Carol
    Fan, Guang
    LEUKEMIA & LYMPHOMA, 2012, 53 (05) : 999 - 1002
  • [44] Novel ZFPL1::NUP98 fusion gene identified in an adult acute myeloid leukemia patient
    Zhu, Yiyan
    Chen, Yu
    Zhang, Fenghong
    Wang, Man
    Lai, Yueyun
    Pan, Jinlan
    Liu, Yizi
    Wang, Qian
    Chen, Suning
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2024, 46 (03) : 568 - 570
  • [45] NUP98::Nsd1 and FLT3-ITD collaborate to generate acute myeloid leukemia
    Matsukawa, Toshihiro
    Yin, Mianmian
    Nigam, Nupur
    Negi, Vijay
    Li, Li
    Small, Donald
    Zhu, Yuelin J.
    Walker, Robert L.
    Meltzer, Paul S.
    Aplan, Peter D.
    LEUKEMIA, 2023, 37 (07) : 1545 - 1548
  • [46] Acute erythroid leukemia is enriched in NUP98 fusions: a report from the Children's Oncology Group
    Chisholm, Karen M.
    Heerema-McKenney, Amy E.
    Choi, John K.
    Smith, Jenny
    Ries, Rhonda E.
    Hirsch, Betsy A.
    Raimondi, Susana C.
    Alonzo, Todd A.
    Wang, Yi-Cheng
    Aplenc, Richard
    Sung, Lillian
    Gamis, Alan S.
    Meshinchi, Soheil
    Kahwash, Samir B.
    BLOOD ADVANCES, 2020, 4 (23) : 6000 - 6008
  • [47] Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome
    Xie, Wei
    Raess, Philipp W.
    Dunlap, Jennifer
    Hoyos, Cristina Magallanes
    Li, Hongmei
    Li, Peng
    Swords, Ronan
    Olson, Susan B.
    Yang, Fei
    Anekpuritanang, Tauangtham
    Hu, Shimin
    Wiszniewska, Joanna
    Fan, Guang
    Press, Richard D.
    Moore, Stephen R.
    LEUKEMIA & LYMPHOMA, 2022, 63 (08) : 1907 - 1916
  • [48] NUP98::Nsd1 and FLT3-ITD collaborate to generate acute myeloid leukemia
    Toshihiro Matsukawa
    Mianmian Yin
    Nupur Nigam
    Vijay Negi
    Li Li
    Donald Small
    Yuelin J. Zhu
    Robert L. Walker
    Paul S. Meltzer
    Peter D. Aplan
    Leukemia, 2023, 37 : 1545 - 1548
  • [49] Targeted gene sequencing and transcriptome sequencing reveal characteristics of NUP98 rearrangement in pediatric acute myeloid leukemia
    Zhang, Jing-Ying
    Chen, Chun-Rong
    Qin, Jia-Yue
    Shen, Di-Ying
    Liu, Li-Xia
    Song, Hua
    Xia, Tian
    Xu, Wei-Qun
    Wang, Yan
    Zhu, Feng
    Fang, Mei-Xin
    Shen, He-Ping
    Liao, Chan
    Dong, Ao
    Cao, Shan-Bo
    Tang, Yong-Min
    Xu, Xiao-Jun
    EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2024, 29 (01)
  • [50] RARG Gene Dysregulation in Acute Myeloid Leukemia
    Conserva, Maria Rosa
    Redavid, Immacolata
    Anelli, Luisa
    Zagaria, Antonella
    Specchia, Giorgina
    Albano, Francesco
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2019, 6
12345