Case report: Successful therapy with azacitidine for acute myeloid leukemia with NUP98::RARG resembling acute promyelocytic leukemia

被引：0
|
作者：
Wei, Zhichen [1 ]
Shao, Linlin [1 ]
Xu, Shuqian [1 ]
Zhang, Xiaolin [1 ]
Wang, Lin [1 ]
Qin, Ping [1 ]
Song, Qiang [1 ]
Hou, Ming [1 ,2 ]
Shi, Yan [1 ]
机构：
[1] Shandong Univ, Qilu Hosp, Dept Hematol, Jinan, Peoples R China
[2] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Shandong Prov Key Lab Immunohematol, Jinan, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词：
acute myeloid leukemia; acute promyelocytic leukemia; all-trans retinoic acid; nucleoporin 98-retinoic acid receptor gamma; azacitidine; RETINOIC ACID; FUSION;
D O I：
10.3389/fonc.2024.1460557
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report a case of acute myeloid leukemia (AML) with retinoic acid receptor gamma (RARG) rearrangement, exhibiting clinical, morphological, and immunophenotypic features similar to classic acute promyelocytic leukemia (APL). RNA sequencing analysis of the patient's bone marrow samples revealed the presence of nucleoporin 98 (NUP98)-RARG caused by translocation. AML with RARG rearrangement is insensitive to all-trans retinoic acid (ATRA) and arsenic trioxide. The patient received azacitidine therapy after failing ATRA and standard 3 + 7 therapy (idarubicin and cytarabine) and achieved complete remission. Conclusively, this acute myeloid leukemia subtype may benefit from azacitidine.
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页数：6
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