Cellular and molecular biology of posttranslational modifications in cardiovascular disease

被引:0
|
作者
Zhu, Li [1 ,2 ]
Liu, Yong-Ping [3 ]
Huang, Yu-Ting [2 ]
Zhou, Zi-Jun [2 ]
Liu, Jian-Feng [4 ]
Yu, Li-Ming [2 ]
Wang, Hui-Shan [1 ,2 ]
机构
[1] Dalian Med Univ, Grad Sch, Dalian 116000, Liaoning, Peoples R China
[2] Gen Hosp Northern Theater Command, Dept Cardiovasc Surg, State Key Lab Frigid Zone Cardiovasc Dis, 83 Wenhua Rd, Shenyang 110016, Peoples R China
[3] China Med Univ, Shengjing Hosp, Dept Pediat, Shenyang 110004, Liaoning, Peoples R China
[4] Shenyang Med Coll, Sch Clin Med 1, Shenyang 110034, Liaoning, Peoples R China
关键词
CVD; Post-translational modifications; Acetylation; Ubiquitination; HEART-FAILURE; CARDIOMYOCYTE HYPERTROPHY; LYSINE SUCCINYLATION; ATRIAL-FIBRILLATION; ENERGY-METABOLISM; CARDIAC MYOCYTES; P53; ACETYLATION; PROTEIN-KINASE; SERUM-LEVELS; SUMOYLATION;
D O I
10.1016/j.biopha.2024.117374
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cardiovascular disease (CVD) has now become the leading cause of death worldwide, and its high morbidity and mortality rates pose a great threat to society. Although numerous studies have reported the pathophysiology of CVD, the exact pathogenesis of all types of CVD is not fully understood. Therefore, much more research is still needed to explore the pathogenesis of CVD. With the development of proteomics, many studies have successfully identified the role of posttranslational modifications in the pathogenesis of CVD, including key processes such as apoptosis, cell metabolism, and oxidative stress. In this review, we summarize the progress in the understanding of posttranslational modifications in cardiovascular diseases, including novel protein posttranslational modifications such as succinylation and nitrosylation. Furthermore, we summarize the currently identified histone deacetylase (HDAC) inhibitors used to treat CVD, providing new perspectives on CVD treatment modalities. We critically analyze the roles of posttranslational modifications in the pathogenesis of CVD-related diseases and explore future research directions related to posttranslational modifications in cardiovascular diseases.
引用
收藏
页数:17
相关论文
共 50 条
  • [41] Function and Mechanism of Novel Histone Posttranslational Modifications in Health and Disease
    Xu, Huiwen
    Wu, Maoyan
    Ma, Xiumei
    Huang, Wei
    Xu, Yong
    BIOMED RESEARCH INTERNATIONAL, 2021, 2021
  • [42] Epigenetic modifications in cardiovascular disease
    Lorenzen, Johan M.
    Martino, Filippo
    Thum, Thomas
    BASIC RESEARCH IN CARDIOLOGY, 2012, 107 (02)
  • [43] Epigenetic modifications in cardiovascular disease
    Johan M. Lorenzen
    Filippo Martino
    Thomas Thum
    Basic Research in Cardiology, 2012, 107
  • [44] MOLECULAR AND CELLULAR BIOLOGY OF MALARIA
    BRAUN, R
    BIOESSAYS, 1988, 8 (06) : 194 - 199
  • [45] THE POTENTIAL OF MOLECULAR AND CELLULAR BIOLOGY
    BAGULEY, BC
    NEW ZEALAND MEDICAL JOURNAL, 1988, 101 (856) : 700 - 702
  • [46] THE PROSOMES - MOLECULAR AND CELLULAR BIOLOGY
    SCHERRER, K
    NOTHWANG, HG
    PEREIRA, IS
    BEY, F
    OLINKCOUX, M
    HUESCA, M
    COUX, O
    ARCANGELETTI, C
    CHEZZI, C
    BURI, JF
    DESA, MFG
    PAL, JK
    AKHAYAT, O
    DESA, CM
    MOLECULAR BIOLOGY REPORTS, 1990, 14 (2-3) : 75 - 75
  • [47] Cellular and molecular biology of the liver
    Karpen, SJ
    Crawford, JM
    CURRENT OPINION IN GASTROENTEROLOGY, 1999, 15 (03) : 184 - 191
  • [48] MOLECULAR AND CELLULAR BIOLOGY OF THE LIVER
    MOSHAGE, H
    YAP, SH
    CURRENT OPINION IN GASTROENTEROLOGY, 1993, 9 (03) : 367 - 373
  • [49] Cellular and molecular biology of the liver
    Anwer, MS
    CURRENT OPINION IN GASTROENTEROLOGY, 1998, 14 (03) : 182 - 190
  • [50] Molecular and cellular biology of rhabdomyosarcoma
    De Giovanni, Carla
    Landuzzi, Lorena
    Nicoletti, Giordano
    Lollini, Pier-Luigi
    Nanni, Patrizia
    FUTURE ONCOLOGY, 2009, 5 (09) : 1449 - 1475