Cellular and molecular biology of posttranslational modifications in cardiovascular disease

被引:0
|
作者
Zhu, Li [1 ,2 ]
Liu, Yong-Ping [3 ]
Huang, Yu-Ting [2 ]
Zhou, Zi-Jun [2 ]
Liu, Jian-Feng [4 ]
Yu, Li-Ming [2 ]
Wang, Hui-Shan [1 ,2 ]
机构
[1] Dalian Med Univ, Grad Sch, Dalian 116000, Liaoning, Peoples R China
[2] Gen Hosp Northern Theater Command, Dept Cardiovasc Surg, State Key Lab Frigid Zone Cardiovasc Dis, 83 Wenhua Rd, Shenyang 110016, Peoples R China
[3] China Med Univ, Shengjing Hosp, Dept Pediat, Shenyang 110004, Liaoning, Peoples R China
[4] Shenyang Med Coll, Sch Clin Med 1, Shenyang 110034, Liaoning, Peoples R China
关键词
CVD; Post-translational modifications; Acetylation; Ubiquitination; HEART-FAILURE; CARDIOMYOCYTE HYPERTROPHY; LYSINE SUCCINYLATION; ATRIAL-FIBRILLATION; ENERGY-METABOLISM; CARDIAC MYOCYTES; P53; ACETYLATION; PROTEIN-KINASE; SERUM-LEVELS; SUMOYLATION;
D O I
10.1016/j.biopha.2024.117374
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cardiovascular disease (CVD) has now become the leading cause of death worldwide, and its high morbidity and mortality rates pose a great threat to society. Although numerous studies have reported the pathophysiology of CVD, the exact pathogenesis of all types of CVD is not fully understood. Therefore, much more research is still needed to explore the pathogenesis of CVD. With the development of proteomics, many studies have successfully identified the role of posttranslational modifications in the pathogenesis of CVD, including key processes such as apoptosis, cell metabolism, and oxidative stress. In this review, we summarize the progress in the understanding of posttranslational modifications in cardiovascular diseases, including novel protein posttranslational modifications such as succinylation and nitrosylation. Furthermore, we summarize the currently identified histone deacetylase (HDAC) inhibitors used to treat CVD, providing new perspectives on CVD treatment modalities. We critically analyze the roles of posttranslational modifications in the pathogenesis of CVD-related diseases and explore future research directions related to posttranslational modifications in cardiovascular diseases.
引用
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页数:17
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