The Chemopreventive Impact of Diet-Derived Phytochemicals on the Adipose Tissue and Breast Tumor Microenvironment Secretome

被引：0
|
作者：
Akla, Naoufal [1 ]
Veilleux, Carolane [1 ]
Annabi, Borhane [1 ]
机构：
[1] Univ Quebec Montreal, Dept Chim & CERMO FC, Lab Oncol Mol, CP 8888 Succ Ctr Ville, Montreal, PQ H3C 3P8, Canada
来源：
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2025年 / 77卷 / 01期
基金：
加拿大自然科学与工程研究理事会;
关键词：
NF-KAPPA-B; CASPASE-DEPENDENT APOPTOSIS; CANCER CELLS; EXTRACELLULAR VESICLES; INHIBITS PROLIFERATION; CHRONIC INFLAMMATION; RESISTANCE TRANSFER; CARCINOMA CELLS; DOWN-REGULATION; INDUCED MMP-9;
D O I：
10.1080/01635581.2024.2401647
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer cells-derived extracellular vesicles can trigger the transformation of adipose-derived mesenchymal stem cells (ADMSC) into a pro-inflammatory, cancer-associated adipocyte (CAA) phenotype. Such secretome-mediated crosstalk between the adipose tissue and the tumor microenvironment (TME) therefore impacts tumor progression and metastatic processes. In addition, emerging roles of diet-derived phytochemicals, especially epigallocatechin-3-gallate (EGCG) among other polyphenols, in modulating exosome-mediated metabolic and inflammatory signaling pathways have been highlighted. Here, we discuss how selected diet-derived phytochemicals could alter the secretome signature as well as the crosstalk dynamics between the adipose tissue and the TME, with a focus on breast cancer. Their broader implication in the chemoprevention of obesity-related cancers is also discussed.
引用
收藏
页码：9 / 25
页数：17
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