The Chemopreventive Impact of Diet-Derived Phytochemicals on the Adipose Tissue and Breast Tumor Microenvironment Secretome

被引：0

作者：

Akla, Naoufal ^{[1
]}

Veilleux, Carolane ^{[1
]}

Annabi, Borhane ^{[1
]}

机构：

[1] Univ Quebec Montreal, Dept Chim & CERMO FC, Lab Oncol Mol, CP 8888 Succ Ctr Ville, Montreal, PQ H3C 3P8, Canada

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2025年 / 77卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

NF-KAPPA-B; CASPASE-DEPENDENT APOPTOSIS; CANCER CELLS; EXTRACELLULAR VESICLES; INHIBITS PROLIFERATION; CHRONIC INFLAMMATION; RESISTANCE TRANSFER; CARCINOMA CELLS; DOWN-REGULATION; INDUCED MMP-9;

D O I：

10.1080/01635581.2024.2401647

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer cells-derived extracellular vesicles can trigger the transformation of adipose-derived mesenchymal stem cells (ADMSC) into a pro-inflammatory, cancer-associated adipocyte (CAA) phenotype. Such secretome-mediated crosstalk between the adipose tissue and the tumor microenvironment (TME) therefore impacts tumor progression and metastatic processes. In addition, emerging roles of diet-derived phytochemicals, especially epigallocatechin-3-gallate (EGCG) among other polyphenols, in modulating exosome-mediated metabolic and inflammatory signaling pathways have been highlighted. Here, we discuss how selected diet-derived phytochemicals could alter the secretome signature as well as the crosstalk dynamics between the adipose tissue and the TME, with a focus on breast cancer. Their broader implication in the chemoprevention of obesity-related cancers is also discussed.

引用

页码：9 / 25

页数：17

共 50 条

[31] Voluntary physical activity abolishes the proliferative tumor growth microenvironment created by adipose tissue in animals fed a high fat diet
Theriau, Christopher F.
Shpilberg, Yaniv
Riddell, Michael C.
Connor, Michael K.
JOURNAL OF APPLIED PHYSIOLOGY, 2016, 121 (01) : 139 - 153
[32] IMPACT OF TUMOR IMMUNE MICROENVIRONMENT ON BREAST CANCER PROGRESSION
Kahharov, Alisher
BREAST, 2023, 71 : S47 - S47
[33] The role of tissue-derived extracellular vesicles in tumor microenvironment
Lin, Jin
Lu, Wan
Huang, Bo
Yang, Weiming
Wang, Xiaozhong
TISSUE & CELL, 2024, 89
[34] FUNCTIONAL REGENERATION IN SPINAL CORD INJURY INDUCED BY THE SECRETOME OF ADIPOSE TISSUE DERIVED STEM CELLS
Ribeiro, Jorge
Silva, Rita
Monteiro, Susana
Lima, Rui
Serra, Sofia
Teixeira, Fabio
Graca, Jose
Silva, Nuno
Salgado, Antonio
TISSUE ENGINEERING PART A, 2022, 28 : S187 - S187
[35] Impact of diet-derived signaling molecules on human cognition: exploring the food-brain axis
Rodriguez, Raymond L.
Albeck, John G.
Taha, Ameer Y.
Ori-McKenney, Kassandra M.
Recanzone, Gregg H.
Stradleigh, Tyler W.
Hernandez, Bronte C.
Tang, Feng-Yao Vincent
Chiang, En-Pei Isabel
Cruz-Orengo, Lillian
NPJ SCIENCE OF FOOD, 2017, 1 (01)
[36] Secretome analysis of breast cancer-associated adipose tissue to identify paracrine regulators of breast cancer growth
Lapeire, Lore
Hendrix, An
Lecoutere, Evelyne
Van Bockstal, Mieke
Vandesompele, Jo
Maynard, Dawn
Braems, Geert
Van Den Broecke, Rudy
Muller, Catherine
Bracke, Marc
Cocquyt, Veronique
Denys, Hannelore
De Wever, Olivier
ONCOTARGET, 2017, 8 (29) : 47239 - 47249
[37] Impact of tumor immune microenvironment on prognosis in breast cancer
Takeshita, Takashi
Ohino, Tomohiro
Li, Dong
Moriya, Yumi
Hagio, Kanako
Takabe, Kazuaki
Yamashita, Hiroko
CANCER SCIENCE, 2021, 112 : 159 - 159
[38] IL-6 and CCL5 secretion by adipose-derived stem cells and the breast tumor microenvironment
Vona-Davis, Linda
Lundstrom, Eric
Berrebi, Daniel
Werwie, Nicole
Yadav, Abhishek
CANCER RESEARCH, 2018, 78 (04)
[39] IMPACT OF DIET-DERIVED TRIMETHYLAMINE N-OXIDE (TMAO) ON ENDOTHELIAL DYSFUNCTION: AN IN VITRO STUDY
Querio, G.
Geddo, F.
Antoniotti, S.
Levi, R.
Gallo., M. P.
ATHEROSCLEROSIS, 2021, 331 : E63 - E63
[40] MicroRNAs and Their Impact on Breast Cancer, the Tumor Microenvironment, and Disparities
Evans-Knowell, A.
LaRue, A. C.
Findlay, V. J.
CANCER DISPARITIES, 2017, 133 : 51 - 76

← 1 2 3 4 5 →