Para-selective C-H functionalization of anilines: A review

被引：1
|
作者：
Doraghi, Fatemeh [1 ]
Kalooei, Yasin Mohammadkhani [2 ]
Darban, Negar Mehdi Zadeh [3 ]
Larijani, Bagher [1 ]
Mahdavi, Mohammad [1 ]
机构：
[1] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran
[2] Univ Tehran, Coll Sci, Sch Chem, Tehran, Iran
[3] Khaje Nasir Toosi Univ Technol, Coll Chem, Tehran, Iran
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2024年 / 1019卷
关键词：
Aniline; Para-functionalization; Regioselectivity; Transition metal; Catalytic reactions; METAL; HYDROARYLATION; ALKYLATION; ACTIVATION; ALKENES; DESIGN;
D O I：
10.1016/j.jorganchem.2024.123313
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Controlling the site-selectivity in the C-H functionalization of anilines is one of the great challenges in synthetic chemistry. Considering the numerous applications of aniline derivatives in pharmaceuticals, agrochemicals and advanced materials, the para-selective functionalization of these scaffolds has received much attention. Various synthetic methods on the para-selective functionalization of primary, secondary and tertiary anilines, including electrophilic aromatic reactions, nucleophilic aromatic reactions, oxidative addition, radical addition, and carbenoid addition are highlighted in this review.
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页数：15
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