Para-selective C-H functionalization of anilines: A review

被引：1

作者：

Doraghi, Fatemeh ^{[1
]}

Kalooei, Yasin Mohammadkhani ^{[2
]}

Darban, Negar Mehdi Zadeh ^{[3
]}

Larijani, Bagher ^{[1
]}

Mahdavi, Mohammad ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran

[2] Univ Tehran, Coll Sci, Sch Chem, Tehran, Iran

[3] Khaje Nasir Toosi Univ Technol, Coll Chem, Tehran, Iran

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2024年 / 1019卷

关键词：

Aniline; Para-functionalization; Regioselectivity; Transition metal; Catalytic reactions; METAL; HYDROARYLATION; ALKYLATION; ACTIVATION; ALKENES; DESIGN;

D O I：

10.1016/j.jorganchem.2024.123313

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Controlling the site-selectivity in the C-H functionalization of anilines is one of the great challenges in synthetic chemistry. Considering the numerous applications of aniline derivatives in pharmaceuticals, agrochemicals and advanced materials, the para-selective functionalization of these scaffolds has received much attention. Various synthetic methods on the para-selective functionalization of primary, secondary and tertiary anilines, including electrophilic aromatic reactions, nucleophilic aromatic reactions, oxidative addition, radical addition, and carbenoid addition are highlighted in this review.

引用

页数：15

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