Polyethylene glycol (PEG-400) Mediated One-pot Green Synthesis of 4,7-Dihydro-2H-pyrazolo[3,4-b]pyridines Under Catalyst-free Conditions

被引：15

作者：

Kerru, Nagaraju ^{[1
]}

Gummidi, Lalitha ^{[1
]}

Maddila, Suresh ^{[1
]}

Jonnalagadda, Sreekantha B. ^{[1
]}

机构：

[1] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Chiltern Hills,Private Bag 54001, ZA-4000 Durban, South Africa

来源：

CHEMISTRYSELECT | 2020年 / 5卷 / 40期

关键词：

Catalyst-free; Multicomponent reaction; One-pot; PEG-400; medium; Pyrazolo[3; 4-b]pyridine; RECYCLABLE REACTION MEDIUM; REUSABLE SOLVENT MEDIUM; MULTICOMPONENT REACTIONS; ORGANIC-SYNTHESIS; POLY(ETHYLENE GLYCOL); SUPERCRITICAL FLUIDS; IONIC LIQUIDS; EFFICIENT; HETEROCYCLES; DERIVATIVES;

D O I：

10.1002/slct.202002538

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyethylene glycol (PEG-400) was proved a highly efficient and green solvent reaction medium for the synthesis of series of novel 3,6-dimethyl-4,7-dihydro-2H-pyrazolo[3,4-b]pyridine derivatives with excellent yields by a three-component reaction of 1H-pyrazol-3-amino-5-methyl, various aromatic or heteroaromatic aldehydes and chosen CH-active compounds under catalyst-free conditions via one-pot strategy. This transformation is compatible with a broad diversity of functional group tolerance. Rapid synthesis, mild reaction conditions, high yields, no catalyst or column chromatography, cost-effectiveness and green solvent are the benefits of this protocol.

引用

页码：12407 / 12410

页数：4

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