Polyethylene glycol (PEG-400): an efficient green reaction medium for the synthesis of benzo[4,5]imidazo[1,2-a]-pyrimido[4,5-d]pyrimidin-4(1H)-ones under catalyst-free conditions

被引：27
|
作者：
Reddy, Mudumala Veeranarayana [1 ]
Kim, Jong Su [1 ]
Lim, Kwon Taek [1 ]
Jeong, Yeon Tae [1 ]
机构：
[1] Pukyong Natl Univ, Dept Image Sci & Engn, Pusan 608737, South Korea
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 47期
关键词：
Polyethylene glycol (PEG-400); Benzo[4,5]imidazo[1,2-a]-pyrimido[4,5-d]pyrimidin-4(1H)-ones; 1H-Benzo[d]imidazol-2-amine; Catalyst-free conditions; ONE-POT SYNTHESIS; HIGHLY EFFICIENT; SOLVENT-FREE; MULTICOMPONENT SYNTHESIS; ALPHA-AMINOPHOSPHONATES; DERIVATIVES; INHIBITORS; WATER; ACID; RING;
D O I：
10.1016/j.tetlet.2014.09.135
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and an efficient eco-friendly methodology has been developed for the synthesis of benzo[4,5]imidazo[1,2-a]-pyrimido[4,5-d]pyrimidin-4(1H)-ones in excellent yields under catalyst-free-conditions using inexpensive and non-toxic polyethylene glycol (PEG-400) medium. This new protocol offers an environmental acceptability, shorter reaction time, room temperature, low cost, high yields, and recyclability of the PEG-400 medium are the important features. This method provides a green and much improved protocol over the existing methods. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6459 / 6462
页数：4
相关论文
共 50 条
  • [1] A catalyst-free reaction in water: synthesis of benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives
    Liu, Junhua
    Lei, Min
    Hu, Lihong
    GREEN CHEMISTRY, 2012, 14 (09) : 2534 - 2539
  • [2] Synthesis of novel benzo[4,5]imidazo[1,2-a]pyrimido- [4,5-d]pyrimidine derivatives as potent antimicrobial agents
    Prasoona, G.
    Kishore, B.
    Brahmeshwari, G.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2020, 59 (04): : 445 - 453
  • [3] Microwave-assisted efficient synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine derivatives in water under catalyst-free conditions
    Tu, Shujiang
    Shao, Qingqing
    Zhou, Dianxiang
    Cao, Longji
    Shi, Feng
    Li, Chunmei
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2007, 44 (06) : 1401 - 1406
  • [4] Copper-Catalyzed Domino Synthesis of Benzo[4,5]imidazo[1,2-a]pyrimidin-4(10H)-ones using Cyanamide as a Building Block
    Lou, Zhenbang
    Wu, Xudong
    Yang, Haijun
    Zhu, Changjin
    Fu, Hua
    ADVANCED SYNTHESIS & CATALYSIS, 2015, 357 (18) : 3961 - 3968
  • [5] Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo [1,2-a]pyrimidin-4-ones
    Puttaraju, Kallimeledoddi B.
    Shivashankar, Kalegowda
    Chandra
    Mahendra, M.
    Rasal, Vijaykumar P.
    Vivek, Ponnuru N. Venkata
    Rai, Khushboo
    Chanu, Maibam Beebina
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 69 : 316 - 322
  • [6] Green and Catalyst-Free Synthesis of Some New Benzo[4,5]imidazo[1,2-a]pyrimidine Derivatives as Antimicrobial and Antitubercular Agents
    Panchani, N. M.
    Joshi, H. S.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 58 (04) : 604 - 611
  • [7] Green and Catalyst-Free Synthesis of Some New Benzo[4,5]imidazo[1,2-a]pyrimidine Derivatives as Antimicrobial and Antitubercular Agents
    N. M. Panchani
    H. S. Joshi
    Russian Journal of Organic Chemistry, 2022, 58 : 604 - 611
  • [8] Design and Synthesis of Pyrimido [4,5-d]pyrimidin-4(3H)-ones as Selective L3MBTL1 Binders
    Zhou Hao
    Che Xin
    Peng Li
    Wang Na
    Bai Xu
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2016, 37 (07): : 1293 - 1301
  • [9] 2-Trifluoromethyl-10H-benzo[4,5]imidazo[1,2-a] pyrimidin-4-one
    Chandra
    Puttaraju, K. B.
    Shivashankar, K.
    Babu, E. A. Jithesh
    Mahendra, M.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2013, 69 : O1536 - +
  • [10] Synthesis of α1-oxindole-α-hydroxyphosphonates under catalyst-free conditions using polyethylene glycol (PEG-400) as an efficient and recyclable reaction medium
    Nagarapu, Lingaiah
    Mallepalli, Raghu
    Kumar, U. Nikhil
    Venkateswarlu, P.
    Bantu, Rajashaker
    Yeramanchi, Lingappa
    TETRAHEDRON LETTERS, 2012, 53 (14) : 1699 - 1700
12345