Systemic osteosclerosis associated with primary bone marrow B-cell lymphoma

被引：1

作者：

Ozaki, Shuji ^{[1
]}

Iima, Tsutomu ^{[2
]}

Sekimoto, Etsuko ^{[1
]}

Shibata, Hironobu ^{[1
]}

Shigekiyo, Toshio ^{[1
]}

Higuchi, Yukio ^{[3
]}

Hirose, Takanori ^{[4
]}

机构：

[1] Tokushima Prefecture Cent Hosp, Dept Hematol, 1-10-3 Kuramoto, Tokushima 7708539, Japan

[2] Tokushima Prefecture Cent Hosp, Dept Cardiovasc Med, Tokushima, Japan

[3] Tokushima Prefecture Cent Hosp, Dept Orthoped Surg, Tokushima, Japan

[4] Tokushima Prefecture Cent Hosp, Dept Diagnost Pathol, Tokushima, Japan

来源：

EJHAEM | 2023年 / 4卷 / 02期

关键词：

osteoprotegerin; osteosclerosis; primary bone marrow B-cell lymphoma; DIFFUSE OSTEOSCLEROSIS; MYELOFIBROSIS; LEUKEMIA; OSTEOPROTEGERIN;

D O I：

10.1002/jha2.652

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic osteosclerosis is a rare complication of hematological malignancies. Primary myelofibrosis and acute megakaryocytic leukemia are known as underlying diseases; however, lymphoid tumors have rarely been reported. Here we describe a case of a 50-year-old man with severe systemic osteosclerosis associated with primary bone marrow B-cell lymphoma. Analysis of bone metabolic markers revealed a high turnover of bone metabolism and an increase in serum osteoprotegerin levels. These results suggest the involvement of osteoprotegerin in the pathogenesis of osteosclerosis associated with hematological malignancies.

引用

页码：483 / 487

页数：5

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