Systemic osteosclerosis associated with primary bone marrow B-cell lymphoma

被引：1
|
作者：
Ozaki, Shuji [1 ]
Iima, Tsutomu [2 ]
Sekimoto, Etsuko [1 ]
Shibata, Hironobu [1 ]
Shigekiyo, Toshio [1 ]
Higuchi, Yukio [3 ]
Hirose, Takanori [4 ]
机构：
[1] Tokushima Prefecture Cent Hosp, Dept Hematol, 1-10-3 Kuramoto, Tokushima 7708539, Japan
[2] Tokushima Prefecture Cent Hosp, Dept Cardiovasc Med, Tokushima, Japan
[3] Tokushima Prefecture Cent Hosp, Dept Orthoped Surg, Tokushima, Japan
[4] Tokushima Prefecture Cent Hosp, Dept Diagnost Pathol, Tokushima, Japan
来源：
EJHAEM | 2023年 / 4卷 / 02期
关键词：
osteoprotegerin; osteosclerosis; primary bone marrow B-cell lymphoma; DIFFUSE OSTEOSCLEROSIS; MYELOFIBROSIS; LEUKEMIA; OSTEOPROTEGERIN;
D O I：
10.1002/jha2.652
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Systemic osteosclerosis is a rare complication of hematological malignancies. Primary myelofibrosis and acute megakaryocytic leukemia are known as underlying diseases; however, lymphoid tumors have rarely been reported. Here we describe a case of a 50-year-old man with severe systemic osteosclerosis associated with primary bone marrow B-cell lymphoma. Analysis of bone metabolic markers revealed a high turnover of bone metabolism and an increase in serum osteoprotegerin levels. These results suggest the involvement of osteoprotegerin in the pathogenesis of osteosclerosis associated with hematological malignancies.
引用
收藏
页码：483 / 487
页数：5
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