Rare-variant association study

被引：0
|
作者：
Wang, Yin [1 ]
Chan, Ying Wai [1 ]
机构：
[1] Univ Hong Kong, Sch Biol Sci, Pokfulam, Hong Kong, Peoples R China
来源：
CELL GENOMICS | 2024年 / 4卷 / 05期
关键词：
MISSING HERITABILITY;
D O I：
10.1016/j.xgen.2024.100558
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this issue of Cell Genomics , Wang, Liu, Zuo, Wang, et al. 1 investigate rare variants in hepatocellular carcinoma (HCC) by performing the first rare -variant association study (RVAS) in a Chinese population cohort. It uncovers BRCAness phenotypes associated with the NRDE2-p.N377I variant, suggesting PARP inhibitors as a promising therapeutic approach for certain HCC patients.
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