Base-Promoted Synthesis of Isoquinolines through a Tandem Reaction of 2-Methyl-arylaldehydes and Nitriles

被引：1

作者：

Shuai, Sujuan ^{[1
,2
,4
]}

Mao, Jianyou ^{[3
]}

Zhou, Fan ^{[1
,2
,4
]}

Yan, Qifeng ^{[1
,2
]}

Chen, Lingfeng ^{[1
]}

Li, Jie ^{[1
,2
]}

Walsh, Patrick J. ^{[5
]}

Liang, Guang ^{[1
]}

机构：

[1] Hangzhou Med Coll, Sch Pharmaceut Sci, Hangzhou 311399, Zhejiang, Peoples R China

[2] Zhejiang Univ City Coll, Sch Med, Dept Pharm, Hangzhou 310015, Peoples R China

[3] Nanjing Tech Univ, Inst Adv Synth, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China

[4] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China

[5] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 10期

基金：

美国国家科学基金会;

关键词：

IRIDIUM COMPLEXES; BETA-PHENYLETHYLAMINES; EFFICIENT SYNTHESIS; DERIVATIVES; FUNCTIONALIZATION; CYCLIZATION; ALLYLATION; ANNULATION; ALDEHYDES; INDOLES;

D O I：

10.1021/acs.joc.4c00123

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for preparing 3-aryl isoquinolines via a base-promoted tandem reaction is presented. Simply combining commercially available 2-methyl-arylaldehydes, benzonitriles, NaN(SiMe3)(2), and Cs2CO3 enabled the synthesis of a variety of isoquinolines (23 examples, <= 90% yield). Among the syntheses of isoquinolines, the transition metal-free method described here is straightforward, practical, and operationally simple.

引用

页码：6793 / 6797

页数：5

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