Base-Promoted Synthesis of Isoquinolines through a Tandem Reaction of 2-Methyl-arylaldehydes and Nitriles

被引：1
|
作者：
Shuai, Sujuan [1 ,2 ,4 ]
Mao, Jianyou [3 ]
Zhou, Fan [1 ,2 ,4 ]
Yan, Qifeng [1 ,2 ]
Chen, Lingfeng [1 ]
Li, Jie [1 ,2 ]
Walsh, Patrick J. [5 ]
Liang, Guang [1 ]
机构：
[1] Hangzhou Med Coll, Sch Pharmaceut Sci, Hangzhou 311399, Zhejiang, Peoples R China
[2] Zhejiang Univ City Coll, Sch Med, Dept Pharm, Hangzhou 310015, Peoples R China
[3] Nanjing Tech Univ, Inst Adv Synth, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China
[4] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China
[5] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 10期
基金：
美国国家科学基金会;
关键词：
IRIDIUM COMPLEXES; BETA-PHENYLETHYLAMINES; EFFICIENT SYNTHESIS; DERIVATIVES; FUNCTIONALIZATION; CYCLIZATION; ALLYLATION; ANNULATION; ALDEHYDES; INDOLES;
D O I：
10.1021/acs.joc.4c00123
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient method for preparing 3-aryl isoquinolines via a base-promoted tandem reaction is presented. Simply combining commercially available 2-methyl-arylaldehydes, benzonitriles, NaN(SiMe3)(2), and Cs2CO3 enabled the synthesis of a variety of isoquinolines (23 examples, <= 90% yield). Among the syntheses of isoquinolines, the transition metal-free method described here is straightforward, practical, and operationally simple.
引用
收藏
页码：6793 / 6797
页数：5
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