HPK1 inhibits CD8+T cell effector gene expression following T cell activation

被引：0
|
作者：
Ames, Rachel Y.
Zhao, Rongqi
Mace, Parker
Grant, Adam
Xie, Guorui
Milestone, Heather
Grandcolas, Molly
Fang, Eva
Kiosea, Nicolae
Wong, Stephen
Brovarney, Martin
Jacobson, Scott
Nebalasca, Danilo
Arguello, Jorge
Gomez, Blanca
Kandala, Hiranmayee
Ko, Michelle Y.
Nguyen, Lan
Robles, Omar
Shibuya, Grant
Shakhmin, Anton A.
Tivitmahaisoon, Parcharee
Vi-Anh Vu
Younai, Ashkaan
Zibinsky, Mikhail
Subramanyam, Babu
Poon, Daniel
Ghomi, Mohsen Sabouri
Wustrow, David J.
Kassner, Paul D.
Katibah, George E.
Brockstedt, Dirk G.
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-2654
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2654
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Expression of intratumoral PD-L1 and intratumoral CD4+T cell, CD8+T cell, and FOXP3+T cell in lung cancer
    Shimada, Hiroyuki
    Yamauchi, Shuta
    Jin, Yasuto
    CANCER SCIENCE, 2018, 109 : 1410 - 1410
  • [42] Mechanistic understanding of HPK1 inhibition on enhanced human T cell activation and tumor immunity in a syngeneic model.
    Ciccone, David
    Lazari, Vad
    Linney, Ian
    Briggs, Michael
    Carreiro, Samantha
    Loh, Christine
    Tummino, Peter
    McElwee, Joshua
    Collis, Alan
    Kaila, Neelu
    CANCER RESEARCH, 2021, 81 (13)
  • [43] HPK1 inhibition enhances T cell activation and relieves the immunosuppressive phenotype of inhibitory signals found in the tumor microenvironment
    Singh, Rajesh K.
    Rayaji, Rameshwari
    Patel, Bindi
    Zhang, Kristen
    Marubayashi, Sachie
    Cho, Soonweng
    Garrido-Shaqfeh, Stefan
    Kulusich, Joseph
    Meleza, Cesar
    Tibrewal, Nidhi
    Thomas, Joice
    Nareddy, Pradeep
    Sharif, Ehesan
    Zhao, Sharon
    Green, David
    Leleti, Manmohan R.
    Powers, Jay P.
    DiRenzo, Daniel
    Walters, Matthew J.
    CANCER RESEARCH, 2022, 82 (12)
  • [44] Pharmacologic inhibition of HPK1 kinase activity enhances immune cell activation and T cell mediated anti-tumor activity
    Lee, Jacob S.
    Toy, Pamela
    Min-Oo, Gundula
    Lee, Tony
    Salvo, Patrick
    Belzile, JeanPhilippe
    Clancy, Sheila
    Nazareno, Jonathan
    Xu, Mengshu
    Xing, Weimei
    Giacomini, Marilyn
    Santos, Rex
    Stapleton, Lance
    Wang, Adele
    Juric, Vladislava
    Mitchell, Scott A.
    Kuhne, Michelle
    CANCER RESEARCH, 2022, 82 (12)
  • [45] Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based Immunotherapy
    Wang, Ming-Shu
    Wang, Zhi-Zheng
    Li, Zi-Long
    Gong, Yi
    Duan, Cheng-Xiang
    Cheng, Qian-Hui
    Huang, Wei
    Yang, Guang-Fu
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (01) : 611 - 626
  • [46] HIV-1 compromises CD8+T cell effector function in Mtb- infected lung
    Lancaster, Katrina L.
    Hogg, Alison E.
    Clement, Cecilia G.
    Aronson, Judith F.
    Endsley, Janice J.
    JOURNAL OF IMMUNOLOGY, 2009, 182
  • [47] CD8+T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor
    Prokhnevska, Nataliya
    Cardenas, Maria A.
    Valanparambil, Rajesh M.
    Sobierajska, Ewelina
    Barwick, Benjamin G.
    Jansen, Caroline
    Moon, Adriana Reyes
    Gregorova, Petra
    delBalzo, Luke
    Greenwald, Rachel
    Bilen, Mehmet Asim
    Alemozaffar, Mehrdad
    Joshi, Shreyas
    Cimmino, Cara
    Larsen, Christian
    Master, Viraj
    Sanda, Martin
    Kissick, Haydn
    IMMUNITY, 2023, 56 (01) : 107 - +
  • [48] WASp regulates effector-to-memory conversion and maintenance of CD8+T cell memory
    Qiao, L.
    Xiaodong, Z.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 713 - 713
  • [49] Ketolysis drives CD8+T cell effector function through effects on histone acetylation
    Luda, Katarzyna M.
    Longo, Joseph
    Kitchen-Goosen, Susan M.
    Duimstra, Lauren R.
    Ma, Eric H.
    Watson, McLane J.
    Oswald, Brandon M.
    Fu, Zhen
    Madaj, Zachary
    Kupai, Ariana
    Dickson, Bradley M.
    DeCamp, Lisa M.
    Dahabieh, Michael S.
    Compton, Shelby E.
    Teis, Robert
    Kaymak, Irem
    Lau, Kin H.
    Kelly, Daniel P.
    Puchalska, Patrycja
    Williams, Kelsey S.
    Krawczyk, Connie M.
    Levesque, Dominique
    Boisvert, Francois-Michel
    Sheldon, Ryan D.
    Rothbart, Scott B.
    Crawford, Peter A.
    Jones, Russell G.
    IMMUNITY, 2023, 56 (09) : 2021 - +
  • [50] WASp Is Essential for Effector-to-Memory conversion and for Maintenance of CD8+T Cell Memory
    Liu, Qiao
    Zhang, Liang
    Shu, Zhou
    Yu, Tingting
    Zhou, Lina
    Song, Wenxia
    Zhao, Xiaodong
    FRONTIERS IN IMMUNOLOGY, 2019, 10
12345