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- [1] A highly potent HPK1 inhibitor augments immune cell activation and anti-tumor immunity in a syngeneic tumor mouse modelMOLECULAR CANCER THERAPEUTICS, 2021, 20 (12)Liu, Hao论文数: 0 引用数: 0 h-index: 0Wu, Lei论文数: 0 引用数: 0 h-index: 0Feng, Song论文数: 0 引用数: 0 h-index: 0Huang, Wei论文数: 0 引用数: 0 h-index: 0Li, Huijuan论文数: 0 引用数: 0 h-index: 0Lin, Jing论文数: 0 引用数: 0 h-index: 0Liu, Yangyang论文数: 0 引用数: 0 h-index: 0Mei, Liufeng论文数: 0 引用数: 0 h-index: 0Ren, Baoqi论文数: 0 引用数: 0 h-index: 0Xie, Julie论文数: 0 引用数: 0 h-index: 0Yao, Lili论文数: 0 引用数: 0 h-index: 0Zhong, Wenge论文数: 0 引用数: 0 h-index: 0
- [2] A highly selective and potent HPK1 inhibitor enhances immune cell activation and induces robust tumor growth inhibition in a murine syngeneic tumor modelEUROPEAN JOURNAL OF CANCER, 2020, 138 : S20 - S20Ciccone, D.论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Res & Dev, Cambridge, MA USA Nimbus Therapeut, Res & Dev, Cambridge, MA USALazari, V.论文数: 0 引用数: 0 h-index: 0机构: Charles River Labs, Res, Chesterford Pk, England Nimbus Therapeut, Res & Dev, Cambridge, MA USALinney, I.论文数: 0 引用数: 0 h-index: 0机构: Charles River Labs, Res, Chesterford Pk, England Nimbus Therapeut, Res & Dev, Cambridge, MA USABriggs, M.论文数: 0 引用数: 0 h-index: 0机构: Charles River Labs, Res, Chesterford Pk, England Nimbus Therapeut, Res & Dev, Cambridge, MA USACarreiro, S.论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Res & Dev, Cambridge, MA USA Nimbus Therapeut, Res & Dev, Cambridge, MA USAWaddell, I.论文数: 0 引用数: 0 h-index: 0机构: Charles River Labs, Res, Chesterford Pk, England Nimbus Therapeut, Res & Dev, Cambridge, MA USAHill, C.论文数: 0 引用数: 0 h-index: 0机构: Charles River Labs, Res, Chesterford Pk, England Nimbus Therapeut, Res & Dev, Cambridge, MA USALoh, C.论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Res & Dev, Cambridge, MA USA Nimbus Therapeut, Res & Dev, Cambridge, MA USATummino, P.论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Res & Dev, Cambridge, MA USA Nimbus Therapeut, Res & Dev, Cambridge, MA USACollis, A.论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Res & Dev, Cambridge, MA USA Nimbus Therapeut, Res & Dev, Cambridge, MA USAKaila, N.论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Res & Dev, Cambridge, MA USA Nimbus Therapeut, Res & Dev, Cambridge, MA USA
- [3] A HIGHLY SELECTIVE AND POTENT HPK1 INHIBITOR ENHANCES IMMUNE CELL ACTIVATION AND INDUCES ROBUST TUMOR GROWTH INHIBITION IN A MURINE SYNGENEIC TUMOR MODELJOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A411 - A411Ciccone, David论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Cambridge, MA USA Nimbus Therapeut, Cambridge, MA USALazari, Vad论文数: 0 引用数: 0 h-index: 0机构: Charles River Labs, Chesterford Res Pk, Cambridge, England Nimbus Therapeut, Cambridge, MA USALinney, Ian论文数: 0 引用数: 0 h-index: 0机构: Charles River Labs, Chesterford Res Pk, Cambridge, England Nimbus Therapeut, Cambridge, MA USABriggs, Michael论文数: 0 引用数: 0 h-index: 0机构: Charles River Labs, Chesterford Res Pk, Cambridge, England Nimbus Therapeut, Cambridge, MA USACarreiro, Samantha论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Cambridge, MA USA Nimbus Therapeut, Cambridge, MA USAMcElwee, Joshua论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Cambridge, MA USA Nimbus Therapeut, Cambridge, MA USAWaddell, Ian论文数: 0 引用数: 0 h-index: 0机构: Charles River Labs, Chesterford Res Pk, Cambridge, England Nimbus Therapeut, Cambridge, MA USAHill, Chris论文数: 0 引用数: 0 h-index: 0机构: Charles River Labs, Chesterford Res Pk, Cambridge, England Nimbus Therapeut, Cambridge, MA USALoh, Christine论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Cambridge, MA USA Nimbus Therapeut, Cambridge, MA USATummino, Peter论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Cambridge, MA USA Nimbus Therapeut, Cambridge, MA USACollis, Alan论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Cambridge, MA USA Nimbus Therapeut, Cambridge, MA USAKaila, Neelu论文数: 0 引用数: 0 h-index: 0机构: Nimbus Therapeut, Cambridge, MA USA Nimbus Therapeut, Cambridge, MA USA
- [4] HPK1 inhibition enhances T cell activation and relieves the immunosuppressive phenotype of inhibitory signals found in the tumor microenvironmentCANCER RESEARCH, 2022, 82 (12)Singh, Rajesh K.论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USARayaji, Rameshwari论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USAPatel, Bindi论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USAZhang, Kristen论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USAMarubayashi, Sachie论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USACho, Soonweng论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USAGarrido-Shaqfeh, Stefan论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USAKulusich, Joseph论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USAMeleza, Cesar论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USATibrewal, Nidhi论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USAThomas, Joice论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USANareddy, Pradeep论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USASharif, Ehesan论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USAZhao, Sharon论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USAGreen, David论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USALeleti, Manmohan R.论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USAPowers, Jay P.论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USADiRenzo, Daniel论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USAWalters, Matthew J.论文数: 0 引用数: 0 h-index: 0机构: Arcus Biosci Inc, Hayward, CA USA Arcus Biosci Inc, Hayward, CA USA
- [5] Releasing the break on T cell activation through novel small molecule inhibition of HPK1JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7Shen, Minhui论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Waltham, MA USA AstraZeneca, Waltham, MA USABommakanti, Gayathri论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Waltham, MA USA AstraZeneca, Waltham, MA USAMele, Deanna论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Waltham, MA USA AstraZeneca, Waltham, MA USAGrimster, Neil论文数: 0 引用数: 0 h-index: 0机构: AstraZeneca, Waltham, MA USA AstraZeneca, Waltham, MA USA
- [6] Pharmacologic inhibition of HPK1 kinase activity enhances immune cell activation and T cell mediated anti-tumor activityCANCER RESEARCH, 2022, 82 (12)Lee, Jacob S.论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USAToy, Pamela论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USAMin-Oo, Gundula论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USALee, Tony论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USASalvo, Patrick论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USABelzile, JeanPhilippe论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USAClancy, Sheila论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USANazareno, Jonathan论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USAXu, Mengshu论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USAXing, Weimei论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USAGiacomini, Marilyn论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USASantos, Rex论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USAStapleton, Lance论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USAWang, Adele论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USAJuric, Vladislava论文数: 0 引用数: 0 h-index: 0机构: Pionyr Immunotherapeut, San Francisco, CA USA Gilead Sci, Foster City, CA USAMitchell, Scott A.论文数: 0 引用数: 0 h-index: 0机构: Silverback Therapeut, Seattle, WA USA Gilead Sci, Foster City, CA USAKuhne, Michelle论文数: 0 引用数: 0 h-index: 0机构: Gilead Sci, Foster City, CA USA Gilead Sci, Foster City, CA USA
- [7] HPK1 kinase inhibitor: a sufficient approach to target HPK1 to modulate T cell activation in cancer immunotherapy compared with degradersFRONTIERS IN IMMUNOLOGY, 2025, 16Wang, Qin论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaZhu, Xinyi论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaLi, Jing论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Med Chem, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaXu, Sanjia论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Med Chem, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaWang, Ali论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaZhang, Xinwen论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaWang, Xingxing论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Med Chem, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaCai, Xiaopeng论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Med Chem, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaXing, Haimei论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaLiu, Ye论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaLiu, Xuesong论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaWang, Zhiwei论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Med Chem, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaWang, Lai论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R China BeiGene Beijing Co Ltd, Res & Clin Dev, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R ChinaYuan, Xi论文数: 0 引用数: 0 h-index: 0机构: BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R China BeiGene Beijing Co Ltd, Dept Biol, Beijing, Peoples R China
- [8] BB5523, a multiple kinase inhibitor with HPK1, VEGFR2 and TNIK inhibition, enhanced antitumor immunity in tumor modelsCANCER RESEARCH, 2024, 84 (06)Duan, Gongping论文数: 0 引用数: 0 h-index: 0Li, Min论文数: 0 引用数: 0 h-index: 0Zhang, Puyong论文数: 0 引用数: 0 h-index: 0Hua, Wei论文数: 0 引用数: 0 h-index: 0Hao, Enlun论文数: 0 引用数: 0 h-index: 0Wang, Shipeng论文数: 0 引用数: 0 h-index: 0Ma, Xiaoyi论文数: 0 引用数: 0 h-index: 0Wang, Junheng论文数: 0 引用数: 0 h-index: 0Wei, Lijie论文数: 0 引用数: 0 h-index: 0Zhang, Xingmin论文数: 0 引用数: 0 h-index: 0
- [9] The role of HPK1 in the regulation of T cell function and anti-tumor immune activityCANCER RESEARCH, 2020, 80 (16)Chen, Yaoyu论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USARios-Doria, Jonathan论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAPusey, Michelle论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USALasky, Kerri论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAYe, Min论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAThekkat, Pramod论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAGallagher, Karen论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAStump, Kristine论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAConlen, Patricia论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAGardiner, Christine论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAWang, Hui论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USASokolsky, Alexander论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USARupar, Mark论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USALin, Luping论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USABehshad, Elham论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USACovington, Maryanne论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAKoblish, Holly论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAVechorkin, Oleg论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAYao, Wenqing论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAKim, Sunkyu论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USAChen, Yingnan论文数: 0 引用数: 0 h-index: 0机构: Incyte Corp, Wilmington, DE USA Incyte Corp, Wilmington, DE USA
- [10] HPK1 inhibits CD8+T cell effector gene expression following T cell activationCANCER RESEARCH, 2024, 84 (06)Ames, Rachel Y.论文数: 0 引用数: 0 h-index: 0Zhao, Rongqi论文数: 0 引用数: 0 h-index: 0Mace, Parker论文数: 0 引用数: 0 h-index: 0Grant, Adam论文数: 0 引用数: 0 h-index: 0Xie, Guorui论文数: 0 引用数: 0 h-index: 0Milestone, Heather论文数: 0 引用数: 0 h-index: 0Grandcolas, Molly论文数: 0 引用数: 0 h-index: 0Fang, Eva论文数: 0 引用数: 0 h-index: 0Kiosea, Nicolae论文数: 0 引用数: 0 h-index: 0Wong, Stephen论文数: 0 引用数: 0 h-index: 0Brovarney, Martin论文数: 0 引用数: 0 h-index: 0Jacobson, Scott论文数: 0 引用数: 0 h-index: 0Nebalasca, Danilo论文数: 0 引用数: 0 h-index: 0Arguello, Jorge论文数: 0 引用数: 0 h-index: 0Gomez, Blanca论文数: 0 引用数: 0 h-index: 0Kandala, Hiranmayee论文数: 0 引用数: 0 h-index: 0Ko, Michelle Y.论文数: 0 引用数: 0 h-index: 0Nguyen, Lan论文数: 0 引用数: 0 h-index: 0Robles, Omar论文数: 0 引用数: 0 h-index: 0Shibuya, Grant论文数: 0 引用数: 0 h-index: 0Shakhmin, Anton A.论文数: 0 引用数: 0 h-index: 0Tivitmahaisoon, Parcharee论文数: 0 引用数: 0 h-index: 0Vi-Anh Vu论文数: 0 引用数: 0 h-index: 0Younai, Ashkaan论文数: 0 引用数: 0 h-index: 0Zibinsky, Mikhail论文数: 0 引用数: 0 h-index: 0Subramanyam, Babu论文数: 0 引用数: 0 h-index: 0Poon, Daniel论文数: 0 引用数: 0 h-index: 0Ghomi, Mohsen Sabouri论文数: 0 引用数: 0 h-index: 0Wustrow, David J.论文数: 0 引用数: 0 h-index: 0Kassner, Paul D.论文数: 0 引用数: 0 h-index: 0Katibah, George E.论文数: 0 引用数: 0 h-index: 0Brockstedt, Dirk G.论文数: 0 引用数: 0 h-index: 0