A selective, potent, and orally bioavailable CDK7 inhibitor demonstrates superior anti-cancer activity in colorectal cancer models

被引：0
|
作者：
Park, Heuijoon
Seo, Kyoungwan
Yu, Jihyun
Kim, Jieun
Joo, Min Sung
Kim, Sungeun
Lee, Joonhyung
Lee, Jeonghyeon
Kim, Eun-Jung
Nam, Joonwoo
Han, Wooseok
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2024-LB168
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
LB168
引用
收藏
页数：2
相关论文
共 50 条
  • [1] ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment
    Patel, Hetal
    Periyasamy, Manikandan
    Sava, Georgina P.
    Bondke, Alexander
    Slafer, Brian W.
    Kroll, Sebastian H. B.
    Barbazanges, Marion
    Starkey, Richard
    Ottaviani, Silvia
    Harrod, Alison
    Aboagye, Eric O.
    Buluwela, Laki
    Fuchter, Matthew J.
    Barrett, Anthony G. M.
    Coombes, R. Charles
    Ali, Simak
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (06) : 1156 - 1166
  • [2] ICEC0942, an orally bioavailable selective inhibitor of CDK7 for breast cancer
    Ali, Simak
    Patel, Hetal
    Periyasamy, Manikandan
    Bondke, Alexander
    Slafer, Brian W.
    Ottaviani, Silvia
    Harrod, Alison
    Buluwela, Laki
    Fuchter, Matthew J.
    Barrett, Anthony G. M.
    Coombes, R. Charles
    BREAST CANCER RESEARCH AND TREATMENT, 2016, 159 (01) : 195 - 195
  • [3] In vitro anti-cancer activity of UD-017, a novel potent & highly selective CDK7 reversible inhibitor
    Matsushita, Takashi
    Onuma, Kazuhiro
    Sunamoto, Hidetoshi
    Ogawa, Ayumi
    Ogi, Sayaka
    Hasegawa, Toni
    Kono, Shigeyuki
    Iwase, Noriaki
    Aga, Yasuhiro
    Ushiyama, Shigeru
    CANCER RESEARCH, 2017, 77
  • [4] Activity of SY-5609, an oral, noncovalent, potent, and selective CDK7 inhibitor, in preclinical models of colorectal cancer.
    Johannessen, Liv
    Ke, Nan
    Sawant, Priyanka
    Dworakowski, Wojciech
    D'Ippolito, Anthony
    Hu, Shanhu
    Rajagopal, Nisha
    Eaton, Matthew
    Hodgson, Graeme
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [5] Highly selective, orally available CDK7 inhibitor for cancer therapy
    Jeon, Yeejin
    Yu, Donghoon
    Seo, Mooyoung
    Kim, June
    Shin, Jaehee
    Kang, Hwankyu
    Ahn, Jiye
    Choi, Jinho
    Ahn, Seohyun
    Kim, Jaeseung
    Nam, Kiyean
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (01)
  • [6] An oral and selective CDK7 inhibitor demonstrates substantial anti-tumor effect in breast and ovarian cancer models
    Hu, S.
    Marineau, J.
    Bradley, M.
    Hamman, K.
    Alnemy, S.
    Smith, D.
    Carulli, J.
    Chuaqui, C.
    EUROPEAN JOURNAL OF CANCER, 2018, 103 : E39 - E40
  • [7] SY-5609, an orally available selective CDK7 inhibitor demonstrates broad anti-tumor activity in vivo
    Hu, Shanhu
    Marineau, Jason
    Hamman, Kristin
    Bradley, Michael
    Savinainen, Anneli
    Alnemy, Sydney
    Rajagopal, Nisha
    Orlando, David
    Chuaqui, Claudio
    Olson, Eric
    CANCER RESEARCH, 2019, 79 (13)
  • [8] ARTS-021 is a potent and selective CDK2 inhibitor that demonstrates anti-cancer activity in preclinical cancer models with CCNE1 amplification
    Liang, Jiaqi
    Cheng, Dai
    Guo, Yali
    Zhang, Xiaobin
    Liu, Xipan
    Fu, Jia
    Ding, Qiang
    Xiong, Wen
    Li, Fang
    Chen, Yaoyu
    Sheng, Qing
    CANCER RESEARCH, 2022, 82 (12)
  • [9] Potent anti-tumor activity of a selective and orally bioavailable reversible covalent CDK12 inhibitor
    Khare, Leena
    Poddutoori, Ramulu
    Mukherjee, Subhendu
    Samiulla, D. S.
    Devaraja, T. S.
    Marappan, Sivapriya
    Nayak, Shilpa
    Sivakumar, Sasirekha
    Kaza, Lakshmi
    Tgore, Suraj
    Dhudashiya, Amit
    Raghavendra, N. R.
    Gunnepalli, Bhargav
    Aravind, A. B.
    Amith, A.
    Charamanna, K. B.
    Antony, Thomas
    Nellore, Kavitha
    Daginakatte, Girish
    Chelur, Shekar
    Giri, Sanjeev
    Ramachandra, Murali
    Samajdar, Susanta
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (12)
  • [10] In vivo anti-tumor efficacy of UD-017, a novel highly selective & orally available CDK7 inhibitor, in colorectal cancer cells xenograft models
    Aga, Yasuhiro
    Ogi, Sayaka
    Tokunaga, Yasunori
    Ogawa, Ayumi
    Onuma, Kazuhiro
    Matsushita, Takashi
    Sunamoto, Hidetoshi
    Hasegawa, Tom
    Ushiyama, Shigeru
    CANCER RESEARCH, 2017, 77
12345