Paraneoplastic neuromyelitis optica spectrum disorder associated with ovarian dysgerminoma: a case report and literature review

被引:0
|
作者
Liu, Pan [1 ]
Wang, Shuangying [2 ]
Zhang, Chunhua [1 ]
Li, Yanfang [1 ]
机构
[1] Cent Hosp Shaoyang, Dept Neurol, Shaoyang, Peoples R China
[2] Cent Hosp Shaoyang, Dept Clin Pharm, Shaoyang, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
paraneoplastic NMOSD; AQP4; ovarian dysgerminoma; immunosuppression; IVMP; MARKER;
D O I
10.3389/fimmu.2024.1424243
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Neuromyelitis optica spectrum disorder (NMOSD) is a clinical syndrome characterized by attacks of acute optic neuritis and transverse myelitis. We report a case with paraneoplastic NMOSD that improved after immunosuppressive therapy, surgical resection, and chemotherapy. A 48-year-old woman initially presented with gradual binocular visual loss over the course of one week. The patient was evaluated using magnetic resonance imaging (MRI), computed tomography (CT), visual evoked potential (VEP), pathological biopsy, immunohistochemistry, and autoimmune antibody testing. The brain MRI findings were normal. The VEP revealed prolonged P100 latencies in the right eye and an absence of significant waves in the left eye. Positive serum AQP4-IgG antibodies were found. The patient was diagnosed as NMOSD. Then the patient responded well to treatment with methylprednisolone. An ovarian tumor was found in the patient using abdominal MRI and CT. The tumor was surgically resected, and a pathological biopsy revealed that it was ovarian dysgerminoma. The patient received four rounds of chemotherapy after surgery. One month after the final chemotherapy treatment, a positron emission tomography (PET) scan revealed no tumor. The vision of the patient gradually recovered and serum AQP4 was negative. Furthermore, we summarized the characteristics of patients diagnosed with paraneoplastic NMOSD associated with ovarian neoplasms in previous studies. This is a characteristic case of overlapping NMOSD and ovarian dysgerminoma, demonstrating the importance of tumor therapy in cases of paraneoplastic NMOSD.
引用
收藏
页数:7
相关论文
共 50 条
  • [23] A Case Report of Seropositive Neuromyelitis Optica Spectrum Disorder
    Atit, Priyanka
    Schneider, Jean-Raphael
    ANNALS OF NEUROLOGY, 2021, 90 : S16 - S16
  • [24] Paraneoplastic systemic lupus erythematosus associated with dysgerminoma: a case report and literature review
    Ben David, Ran
    Abu-Shakra, Mahmoud
    Meirovitz, Mihai
    Test, Tsafnat
    Medvedev, Nikita
    Sagy, Iftach
    INTERNAL AND EMERGENCY MEDICINE, 2024, : 349 - 355
  • [25] Paraneoplastic neuromyelitis optica spectrum disorders: three new cases and a review of the literature
    Cai, Gang
    He, Dian
    Chu, Lan
    Dai, Qingqing
    Xu, Zhu
    Zhang, Yifan
    INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2016, 126 (07) : 660 - 668
  • [26] Paraneoplastic neuromyelitis optica and ovarian teratoma: A case series
    Bernard-Valnet, Raphael
    Cobo-Calvo, Alvaro
    Siegfried, Aurore
    Marasescu, Raluca
    Bonnan, Mickael
    Ballan, Guillaume
    Ellie, Emmanuel
    Bauer, Jan
    Uro-Coste, Emmanuelle
    Marignier, Romain
    Brassat, David
    MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2019, 31 : 97 - 100
  • [27] Neuromyelitis optica spectrum disorder as a paraneoplastic disorder in a patient with breast cancer
    Vargas, W.
    Gauthier, S.
    Nealon, N.
    Vartanian, T.
    Perumal, J.
    MULTIPLE SCLEROSIS JOURNAL, 2012, 18 : 67 - 68
  • [28] Japanese cases of neuromyelitis optica spectrum disorder associated with myasthenia gravis and a review of the literature
    Ikeguchi, Ryotaro
    Shimizu, Yuko
    Suzuki, Shigeaki
    Shimizu, Satoru
    Kabasawa, Chiaki
    Hashimoto, Shiori
    Masuda, Masayuki
    Nagane, Yuriko
    Utsugisawa, Kimiaki
    Suzuki, Yasushi
    Takahashi, Toshiyuki
    Utsumi, Hiroya
    Fujihara, Kazuo
    Suzuki, Norihiro
    Uchiyama, Shinichiro
    CLINICAL NEUROLOGY AND NEUROSURGERY, 2014, 125 : 217 - 221
  • [29] Neuromyelitis optica spectrum disorders associated with secondary Sjogren's syndrome; a case report and review of the literature
    Shahbeigi, Saeed
    Eftekhari, Seyed Mohammad
    Bolourchian, Mojdeh
    Ahmadzadeh, Arman
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2023, 455
  • [30] Paraneoplastic neuromyelitis optica spectrum disorders: a case series
    Virgilio, Eleonora
    Vecchio, Domizia
    Vercellino, Marco
    Naldi, Paola
    Tesser, Fabiana
    Cantello, Roberto
    Cavalla, Paola
    Comi, Cristoforo
    NEUROLOGICAL SCIENCES, 2021, 42 (06) : 2519 - 2522