Paraneoplastic neuromyelitis optica spectrum disorder associated with ovarian dysgerminoma: a case report and literature review

被引:0
|
作者
Liu, Pan [1 ]
Wang, Shuangying [2 ]
Zhang, Chunhua [1 ]
Li, Yanfang [1 ]
机构
[1] Cent Hosp Shaoyang, Dept Neurol, Shaoyang, Peoples R China
[2] Cent Hosp Shaoyang, Dept Clin Pharm, Shaoyang, Peoples R China
来源
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词
paraneoplastic NMOSD; AQP4; ovarian dysgerminoma; immunosuppression; IVMP; MARKER;
D O I
10.3389/fimmu.2024.1424243
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Neuromyelitis optica spectrum disorder (NMOSD) is a clinical syndrome characterized by attacks of acute optic neuritis and transverse myelitis. We report a case with paraneoplastic NMOSD that improved after immunosuppressive therapy, surgical resection, and chemotherapy. A 48-year-old woman initially presented with gradual binocular visual loss over the course of one week. The patient was evaluated using magnetic resonance imaging (MRI), computed tomography (CT), visual evoked potential (VEP), pathological biopsy, immunohistochemistry, and autoimmune antibody testing. The brain MRI findings were normal. The VEP revealed prolonged P100 latencies in the right eye and an absence of significant waves in the left eye. Positive serum AQP4-IgG antibodies were found. The patient was diagnosed as NMOSD. Then the patient responded well to treatment with methylprednisolone. An ovarian tumor was found in the patient using abdominal MRI and CT. The tumor was surgically resected, and a pathological biopsy revealed that it was ovarian dysgerminoma. The patient received four rounds of chemotherapy after surgery. One month after the final chemotherapy treatment, a positron emission tomography (PET) scan revealed no tumor. The vision of the patient gradually recovered and serum AQP4 was negative. Furthermore, we summarized the characteristics of patients diagnosed with paraneoplastic NMOSD associated with ovarian neoplasms in previous studies. This is a characteristic case of overlapping NMOSD and ovarian dysgerminoma, demonstrating the importance of tumor therapy in cases of paraneoplastic NMOSD.
引用
收藏
页数:7
相关论文
共 50 条
  • [11] A Rare Case of Paraneoplastic Seronegative Neuromyelitis Optica Spectrum Disorder
    Hwang, Sunpil
    Kaur, Jaskaranpreet
    Kashyap, Richi
    Barlow, Brett
    JOURNAL OF INVESTIGATIVE MEDICINE, 2024, 72 (06)
  • [12] Cerebral cortex impairment in neuromyelitis optica spectrum disorder: A case report and literature review
    Sun Hui
    Sun Xuan
    Huang Dehui
    Wu Lei
    Yu Shengyuan
    MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2019, 32 : 9 - 12
  • [13] Neuromyelitis Optica Spectrum Disorder: A Case Report
    Yaregal, Samson
    Bekele, Nebiyu
    Gebrewold, Yonathan
    Tadesse, Abilo
    INTERNATIONAL MEDICAL CASE REPORTS JOURNAL, 2021, 14 : 643 - 648
  • [14] A case of primary CNS lymphoma associated with neuromyelitis optica spectrum disorder: Is there a paraneoplastic link?
    Sanabria, Emilio Garrido
    Jones, Ryan
    Ou, Alexander
    Syritsyna, Olga
    Sticco, Kristin
    Ma, Yupo
    Kowalska, Agnieszka
    Peyster, Robert
    Coyle, Patricia
    NEUROLOGY, 2019, 92 (15)
  • [15] Neuromyelitis optica spectrum disorder - case report
    Sciegienna-Zdeb, Grazyna
    Mierzwa-Molenda, Marta
    MEDICAL STUDIES-STUDIA MEDYCZNE, 2016, 32 (01) : 45 - 48
  • [16] Neuromyelitis optica spectrum disorders associated with systemic sclerosis: a case report and literature review
    Luca Bollo
    Carlo Santoro
    Giuseppe Libro
    Roberta Pellicciari
    Damiano Paolicelli
    Pietro Iaffaldano
    Maria Trojano
    Neurological Sciences, 2022, 43 : 4015 - 4018
  • [17] Neuromyelitis optica spectrum disorders associated with systemic sclerosis: a case report and literature review
    Bollo, Luca
    Santoro, Carlo
    Libro, Giuseppe
    Pellicciari, Roberta
    Paolicelli, Damiano
    Iaffaldano, Pietro
    Trojano, Maria
    NEUROLOGICAL SCIENCES, 2022, 43 (06) : 4015 - 4018
  • [18] Pediatric Neuromyelitis Optica Spectrum Disorder: Case Series and Literature Review
    Ferilli, Michela Ada Noris
    Paparella, Roberto
    Morandini, Ilaria
    Papetti, Laura
    Talamanca, Lorenzo Figa
    Ruscitto, Claudia
    Ursitti, Fabiana
    Moavero, Romina
    Sforza, Giorgia
    Tarantino, Samuela
    Checchi, Martina Proietti
    Vigevano, Federico
    Valeriani, Massimiliano
    LIFE-BASEL, 2022, 12 (01):
  • [19] Neuromyelitis Optica Spectrum Disorder Resembling Wernicke's Encephalopathy: A Case Report and Review of the Literature
    Lynch, Sloan
    Calveras, Nil Saez
    Amin, Anik
    NEUROHOSPITALIST, 2024, 14 (02): : 213 - 217
  • [20] Neuromyelitis Optica Spectrum Disorder Mimicking Pontine Stroke: A Case Report and Systematic Literature Review
    Huang, Brendan
    Arora, Rohan
    McFarlane, Spencer
    Diamond, Joseph A.
    Najjar, Souhel
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (06)