Neuromyelitis optica spectrum disorder (NMOSD) is a clinical syndrome characterized by attacks of acute optic neuritis and transverse myelitis. We report a case with paraneoplastic NMOSD that improved after immunosuppressive therapy, surgical resection, and chemotherapy. A 48-year-old woman initially presented with gradual binocular visual loss over the course of one week. The patient was evaluated using magnetic resonance imaging (MRI), computed tomography (CT), visual evoked potential (VEP), pathological biopsy, immunohistochemistry, and autoimmune antibody testing. The brain MRI findings were normal. The VEP revealed prolonged P100 latencies in the right eye and an absence of significant waves in the left eye. Positive serum AQP4-IgG antibodies were found. The patient was diagnosed as NMOSD. Then the patient responded well to treatment with methylprednisolone. An ovarian tumor was found in the patient using abdominal MRI and CT. The tumor was surgically resected, and a pathological biopsy revealed that it was ovarian dysgerminoma. The patient received four rounds of chemotherapy after surgery. One month after the final chemotherapy treatment, a positron emission tomography (PET) scan revealed no tumor. The vision of the patient gradually recovered and serum AQP4 was negative. Furthermore, we summarized the characteristics of patients diagnosed with paraneoplastic NMOSD associated with ovarian neoplasms in previous studies. This is a characteristic case of overlapping NMOSD and ovarian dysgerminoma, demonstrating the importance of tumor therapy in cases of paraneoplastic NMOSD.
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Univ Szeged, Fac Gen Med, Dept Neurol, Szeged, HungaryUniv Szeged, Fac Gen Med, Dept Neurol, Szeged, Hungary
Annus, Adam
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Bencsik, Krisztina
Obal, Izabella
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Univ Szeged, Fac Gen Med, Dept Neurol, Szeged, HungaryUniv Szeged, Fac Gen Med, Dept Neurol, Szeged, Hungary
Obal, Izabella
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Kincses, Zsigmond Tamas
Tiszlavicz, Laszlo
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Univ Szeged, Fac Gen Med, Dept Pathol, Szeged, HungaryUniv Szeged, Fac Gen Med, Dept Neurol, Szeged, Hungary
Tiszlavicz, Laszlo
Hoeftberger, Romana
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Med Univ Vienna, Inst Neurol, Vienna, AustriaUniv Szeged, Fac Gen Med, Dept Neurol, Szeged, Hungary
Hoeftberger, Romana
Vecsei, Laszlo
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Univ Szeged, Fac Gen Med, Dept Neurol, Szeged, Hungary
MTA SZTE Neurosci Res Grp, Szeged, HungaryUniv Szeged, Fac Gen Med, Dept Neurol, Szeged, Hungary
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UT Southwestern Med Ctr, Dept Neurol, 5303 Harry Hines Blvd, Dallas, TX 75390 USAUT Southwestern Med Ctr, Dept Neurol, 5303 Harry Hines Blvd, Dallas, TX 75390 USA
Tardo, Lauren
Wang, Cynthia
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UT Southwestern Med Ctr, Dept Neurol, 5303 Harry Hines Blvd, Dallas, TX 75390 USAUT Southwestern Med Ctr, Dept Neurol, 5303 Harry Hines Blvd, Dallas, TX 75390 USA
Wang, Cynthia
Rajaram, Veena
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Childrens Med Ctr, Dept Pathol, Dallas, TX 75235 USAUT Southwestern Med Ctr, Dept Neurol, 5303 Harry Hines Blvd, Dallas, TX 75390 USA
Rajaram, Veena
Greenberg, Benjamin M.
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UT Southwestern Med Ctr, Dept Neurol, 5303 Harry Hines Blvd, Dallas, TX 75390 USAUT Southwestern Med Ctr, Dept Neurol, 5303 Harry Hines Blvd, Dallas, TX 75390 USA
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Kobe Univ, Dept Diagnost Pathol, Grad Sch Med, Kobe, Hyogo, JapanKobe Univ, Div Thorac Surg, Grad Sch Med, 7-5-2 Kusunokicho,Chuou Ku, Kobe, Hyogo 6500017, Japan
Jimbo, Naoe
Chihara, Norio
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Kobe Univ, Div Neurol, Grad Sch Med, Kobe, Hyogo, JapanKobe Univ, Div Thorac Surg, Grad Sch Med, 7-5-2 Kusunokicho,Chuou Ku, Kobe, Hyogo 6500017, Japan
Chihara, Norio
Maniwa, Yoshimasa
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Kobe Univ, Div Thorac Surg, Grad Sch Med, 7-5-2 Kusunokicho,Chuou Ku, Kobe, Hyogo 6500017, JapanKobe Univ, Div Thorac Surg, Grad Sch Med, 7-5-2 Kusunokicho,Chuou Ku, Kobe, Hyogo 6500017, Japan
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All India Inst Med Sci AIIMS Nagpur, Dept Radiodiag & Intervent Radiol, Nagpur, IndiaAll India Inst Med Sci AIIMS Nagpur, Dept Radiodiag & Intervent Radiol, Nagpur, India
Dhok, Avinash
Ratnaparkhi, Chetana
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All India Inst Med Sci AIIMS Nagpur, Dept Radiol, Nagpur, IndiaAll India Inst Med Sci AIIMS Nagpur, Dept Radiodiag & Intervent Radiol, Nagpur, India
Ratnaparkhi, Chetana
Kumar, Santha
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Sree Chitra Tirunal Inst Med Sci & Technol SCTIMST, Dept Imaging Sci & Intervent Neuroradiol, Thiruvananthapuram, IndiaAll India Inst Med Sci AIIMS Nagpur, Dept Radiodiag & Intervent Radiol, Nagpur, India
Kumar, Santha
Manhas, Smarth D.
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All India Inst Med Sci AIIMS Nagpur, Dept Radiol, Nagpur, IndiaAll India Inst Med Sci AIIMS Nagpur, Dept Radiodiag & Intervent Radiol, Nagpur, India
Manhas, Smarth D.
Umredkar, Ashwini
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All India Inst Med Sci AIIMS Nagpur, Dept Radiodiag, Nagpur, IndiaAll India Inst Med Sci AIIMS Nagpur, Dept Radiodiag & Intervent Radiol, Nagpur, India
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Capital Med Univ, Beijing Chaoyang Hosp, Dept Neurol, Gongti South 8th, Beijing 100020, Peoples R ChinaCapital Med Univ, Beijing Chaoyang Hosp, Dept Neurol, Gongti South 8th, Beijing 100020, Peoples R China
Yuan, Junliang
Jia, Zejin
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Capital Med Univ, Beijing Chaoyang Hosp, Dept Neurol, Gongti South 8th, Beijing 100020, Peoples R ChinaCapital Med Univ, Beijing Chaoyang Hosp, Dept Neurol, Gongti South 8th, Beijing 100020, Peoples R China
Jia, Zejin
Qin, Wei
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Capital Med Univ, Beijing Chaoyang Hosp, Dept Neurol, Gongti South 8th, Beijing 100020, Peoples R ChinaCapital Med Univ, Beijing Chaoyang Hosp, Dept Neurol, Gongti South 8th, Beijing 100020, Peoples R China
Qin, Wei
Hu, Wenli
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Capital Med Univ, Beijing Chaoyang Hosp, Dept Neurol, Gongti South 8th, Beijing 100020, Peoples R ChinaCapital Med Univ, Beijing Chaoyang Hosp, Dept Neurol, Gongti South 8th, Beijing 100020, Peoples R China