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How Do Cartilage Lubrication Mechanisms Fail in Osteoarthritis? A Comprehensive Review
被引:3
|作者:
Rajankunte Mahadeshwara, Manoj
[1
,2
]
Al-Jawad, Maisoon
[2
]
Hall, Richard M.
[3
]
Pandit, Hemant
[4
]
El-Gendy, Reem
[2
,5
]
Bryant, Michael
[1
,3
]
机构:
[1] Univ Leeds, Inst Funct Surfaces, Mech Engn, Leeds LS2 9JT, England
[2] Univ Leeds, Fac Dent, Dept Oral Biol, Leeds LS2 9JT, England
[3] Univ Birmingham, Coll Engn & Phys Sci, Sch Engn, Birmingham B15 2TT, England
[4] Univ Leeds, Chapel Allerton Hosp, Leeds Inst Rheumat & Musculoskeletal Med LIRMM, Leeds LS7 4SA, England
[5] Suez Canal Univ, Fac Dent, Dept Oral Pathol, Ismailia 3, Ismailia 8366004, Egypt
来源:
基金:
英国工程与自然科学研究理事会;
关键词:
tissue engineering;
biotribology;
cartilage lubrication;
osteoarthritis treatment;
intra-articular injections;
D O I:
10.3390/bioengineering11060541
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
Cartilage degeneration is a characteristic of osteoarthritis (OA), which is often observed in aging populations. This degeneration is due to the breakdown of articular cartilage (AC) mechanical and tribological properties primarily attributed to lubrication failure. Understanding the reasons behind these failures and identifying potential solutions could have significant economic and societal implications, ultimately enhancing quality of life. This review provides an overview of developments in the field of AC, focusing on its mechanical and tribological properties. The emphasis is on the role of lubrication in degraded AC, offering insights into its structure and function relationship. Further, it explores the fundamental connection between AC mechano-tribological properties and the advancement of its degradation and puts forth recommendations for strategies to boost its lubrication efficiency.
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页数:28
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