Role of hydrogels in osteoarthritis: A comprehensive review

被引:3
|
作者
Xu, Yuan [1 ]
Wang, Jing-Yan [1 ]
Meng, Tian [1 ]
Ma, Xue-Wei [1 ]
Li, Hao [1 ]
Li, Kai [1 ]
机构
[1] Sichuan Tourism Univ, Coll Hlth Ind, 459 Hongling Rd, Chengdu 610100, Sichuan, Peoples R China
关键词
hydrogel; inflammation; osteoarthritis; INTRAARTICULAR INJECTION; CARTILAGE; MICROSPHERES; HYALURONATE; COMPOSITE; MICELLES; DELIVERY; SAFETY;
D O I
10.1111/1756-185X.14968
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Osteoarthritis (OA) is a chronic, degenerative, and age-related disease. It is characterized by chronic inflammation, progressive articular cartilage destruction, and subchondral bone sclerosis. The current effective treatment for OA is limited. Hydrogel is a kind of unique carrier with well-known biocompatibility, softness, and high water content among various biomaterials. Hydrogels are developed for different biomedical applications, for instance, drug delivery, and tissue engineering. To date, a variety of hydrogels-based therapies have been used in OA patients or animal models. In this review, we comprehensively summarized the potential role of hydrogels in chondrocytes proliferation, apoptosis, and inflammatory component production and discussed the impact of hydrogels on OA development. The collection of this information will help better understand the present progress of hydrogels in OA.
引用
收藏
页码:2390 / 2401
页数:12
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